Bone turnover in patients with endogenous Cushings syndrome before and after successful treatment
Szappanos A et al. - Study demonstrates a correlations between serum cortisol and both bone formation and resorption markers in the active phase of Cushing’s syndrome (CS); osteocalcin (OC) may serve as a sensitive biologic marker of glucocorticoid activity in endogenous CS during its active phase and may reflect the clinical cure of the disease. Methods- An investigation of:
- Time course of bone marker changes after the cure of CS, and
- Correlations between bone markers and serum cortisol concns
- 87 pts; followed up to 48 mo after surgical cure
- Serum OC and collagen breakdown products (CTX) in pts were compared with that of 161 healthy controls
Results- OC showed a negative, while CTX displayed a positive correlation with serum cortisol
- Pts with diabetes mellitus and myopathy had lower serum OC leve
- Postoperative OC increased rapidly from the first few days or wks reaching its max at the sixth mo
- It remained stable after the 24th postoperative mo
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