Top osteoporosis Articles in Endocrinology

Osteologix to Continue Development of Osteoporosis Drug
Internet Source, 10/21/2009

Although the designated day is meant to draw attention to osteoporosis, too many Americans are already aware of the ravages of this destructive bone disease. Osteoporosis is the most common bone disease in humans. The National Osteoporosis Foundation estimates that ... people in the U.S. suffer from osteoporosis, a condition in which the bones become weak and susceptible to fracture. Approximately half of all women and a quarter of men over age 50 will have an osteoporosis–related fracture at some point in their lives. [more...]

Lifestyle increases osteoporosis risk: docs
Internet Source, 10/21/2009

Lack of exposure to adequate levels of sunlight, exercise and improper diet can lead to osteoporosis. On World Osteoporosis Day held on Tuesday, doctors at the Apollo Hospital conducted an informative programme on the "silent epidemic". Doctors noted ... osteoporosisrelated injury is not visible but it is true that almost six out of ten fractures and bone injuries in India are caused by osteoporosis. Contrary to assumptions, trauma is not the main cause of serious injuries. [more...]

Evaluation of Compliance with Osteoporosis Treatment Guidelines After Initiation of a Pharmacist-Run Osteoporosis Service at a Family Medicine Clinic
Annals of Pharmacotherapy, 10/15/2009

Shrader SP et al. – A pharmacist–run osteoporosis service significantly improved short–term compliance with guidelines, including ... frequency, pharmacotherapy, calcium and vitamin D supplementation, and nonpharmacologic education. [more...]

A microarray based identification of osteoporosis-related genes in primary culture of human osteoblasts
Bone, 10/27/2009

Trost Z et al. – The results present a novel list of genes and metabolic pathways that may be associated with the pathogenesis of osteoporosis. PTN, CXCL2, COL15A1, IBSP, AOX1, MT1G, GSR ... further studies in the assessment of the genetic susceptibility to osteoporosis. In addition, differences in protein synthesis, cell proliferation rate and response to oxidative stress may also be involved in the pathogenesis of osteoporosis. [more...]

Combination of Two Medications Help Postmenopausal Women with Osteoporosis
MedLinePlus, 10/30/2009

Results from the first large study combining two commonly used osteoporosis treatments suggest that the combination of zoledronic acid and teriparatide could help reduce bone loss in postmenopausal women with osteoporosis, according to research presented ... College of Rheumatology Annual Scientific Meeting in Philadelphia, Pa. [more...]

Osteoporosis, the risk of vertebral fracture, and periodontal disease in an elderly group in Mexico City
Gerodontology, 10/28/2009

Moedano DE et al. – The aims of this study were to identify the possible association of osteoporosis, fracture risk and periodontitis, and consider the role of pharmacological treatment ... of osteoporosis and the periodontal condition. Periodontitis extent was associated with osteoporosis, and tooth loss with fracture risk. [more...]

U.S. Hip Fracture Rate Could Drop 25 Percent With Aggressive Osteoporosis Prevention
ScienceDaily, 11/06/2009

Aggressively managing patients at risk for osteoporosis could reduce the hip fracture rate in the United States by 25 percent, according to a study. The first step must be a more active role by orthopedic surgeons in osteoporosis disease management ... popular press,prevention/gen health,osteoporosis [more...]

Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosis
Arthritis & Rheumatism, 11/10/2009

Carbonare LD et al. – These results suggest that an alteration of osteoblastic differentiation may contribute to the pathogenesis of osteoporosis. The noninvasive approach used in the present study could be proposed ... diseases. Methods Osteogenic differentiation process in MSCs obtained from peripheral blood of 31 patients with osteoporosis and 20 normal donors Cells evaluated by colony-forming unit-fibroblastic assay and cultured in osteogenic medium to analyze transcription factors ... p>Results Circulating MSCs increased in osteoporosis patients compared with normal donors In contrast, gene expression analysis revealed down-regulation of RUNX2, Sp7, COL1A1, SPARC, and SPP1 in patients with osteoporosis, associated with lower OPG:RANKL ratio [more...]

Osteoporosis in children: pediatric and pediatric rheumatology perspective: a review
Pediatric Rheumatology, 10/21/2009

Uziel Y et al. – It is increasingly recognized that osteoporosis affects children as well as adults both as a primary problem and as secondary to various diseases, medications, and lifestyle issues. In this ... review, the authors emphasize the correct diagnosis of osteoporosis in children as opposed to adults, etiology, and pharmaceutical and non–pharmaceutical treatments. [more...]

Patients with Wrist Fractures Are Less Likely to Be Evaluated and Managed for Osteoporosis
Journal of Bone and Joint Surgery, 10/05/2009

Gong HS et al. – Despite a recent increase in the recognition of osteoporosis in patients with fragility fractures, the review of this national cohort indicates that patients with a wrist fracture are less likely to be evaluated and managed for osteoporosis than those with a ... fracture by physicians who are responsible for treating symptomatic fractures. Additional studies and intervention programs are necessary to improve this care gap, beginning with physicians who are responsible for fracture treatment. [more...]