Top acth Articles in Endocrinology

ACTH Deficiency, Higher Doses of Hydrocortisone Replacement, and Radiotherapy Are Independent Predictors of Mortality in Patients with Acromegaly
Journal of Clinical Endocrinology and Metabolism, 10/14/2009

Sherlock M et al. – Radiotherapy and ACTH deficiency are significantly associated with increased mortality in patients with acromegaly. In ACTH ... with increased mortality compared to lower doses. These results have important implications for the treatment of patients with acromegaly and also raise issues as to the optimum hydrocortisone treatment regimens for ACTH–deficient patients. [more...]

ACTH-producing pheochromocytoma: Clinical considerations and concise review of the literature
European Journal of Internal Medicine, 10/12/2009

Nijhoff MF et al. – It clearly demonstrates that the relative contributions of clinical, biochemical, and radiological clues in establishing the correct underlying cause of Cushing's syndrome may ... differ considerably between Cushing's disease and Cushing's syndrome due to ectopic overproduction of ACTH. In addition, the literature concerning ACTH–producing pheochromocytomas is reviewed. [more...]

Medical treatment of Cushing's disease: Overview and recent findings
International Journal of General Medicine, 10/21/2009

ACTH) hypersecretion, is the most common etiology of spontaneous excess cortisol production. The majority of pituitary tumors causing Cushing's disease measure <1 cm and the excess morbidity associated with these tumors is mostly due to the effects of elevated, nonsuppressible, ACTH levels leading ... ndash;directed radiation, bilateral adrenalectomy, or medical therapy. This paper addresses current and novel therapies in various stages of development for Cushing’s disease. [more...]

Technical details influence the diagnostic accuracy of the 1 mcg ACTH stimulation test
European Journal of Endocrinology, 10/14/2009

Wade M et al. – The high rate of abnormal results, especially in the afternoon, and loss of ACTH through tubing, suggest that morning testing and minimal tubing should be adopted to avoid an inappropriate ... standardized protocols would facilitate comparison of studies. [more...]

Familial Glucocorticoid Deficiency with a Point Mutation in the ACTH Receptor: A Case Report
Journal of Korean Medical Science, 10/06/2009

Kim CJ et al. – The report a 2 month–old boy of nonconsanguineous parents, presented with hyperpigmentation. Sequence analysis of the ACTH receptor (MC2R) gene showed a homozygous mutation of D103N [more...]

Hypothalamic-Pituitary-Adrenal Axis Activation in Obstructive Sleep Apnea: The Effect of Continuous Positive Airway Pressure Therapy
Journal of Clinical Endocrinology and Metabolism, 10/15/2009

condition with significant cardiovascular and metabolic comorbidity. Untreated compared to treated OSA is associated with marked disturbances in ACTH and cortisol secretory dynamics, resulting in prolonged tissue exposure to disordered, elevated hormone levels. [more...]

Focal segmental glomerulosclerosis in a patient with isolated ACTH deficiency and reversible hypothyroidism
Clinical and Experimental Nephrology, 10/09/2009

Yamada S et al. – Renal function remains normal at five years after the start of hydrocortisone treatment. The findings suggest that both hydrocortisone therapy and normalized thyroid [more...]

Flexion contractures in secondary adrenal insufficiency
Clinical Rheumatology, 10/22/2009

report the case of a 55–year–old male with flexion contractures of the hips and the knees due to an isolated adrenocorticotropin (ACTH) deficiency, a rare cause of secondary adrenal insufficiency. The aetiology of the flexion contractures in adrenal insufficiency is still unclear. The [more...]

ACTH-Independent Cushing's Syndrome with Bilateral Micronodular Adrenal Hyperplasia and Ectopic Adrenocortical Adenoma
Journal of Clinical Endocrinology and Metabolism, 11/25/2009

Louiset E et al. – This case suggests that unknown molecular defects can favor both micronodular adrenal hyperplasia and ectopic adrenocortical adenoma associated with [more...]

High prevalence of autonomous cortisol and aldosterone secretion from adrenal adenomas
Clinical Endocrinology, 11/17/2009

The authors tested whether the use of appropriate controls and modification of standard testing, aiming at eliminating interference from endogenous ACTH, reveals previously undetected subtle ACS and AAS by SAA. By applying new cut–offs, ACS and AAS in patients with a SAA is very common, and [more...]