Top acth Articles in Endocrinology

Inferior petrosal sinus ACTH and prolactin responses to CRH in ACTH-dependent Cushings syndrome: a single centre experience from the United Kingdom
Pituitary, 09/25/2009

Daousi C et al. – Inferior petrosal sinus sampling (IPSS) of ACTH with CRH stimulation helps distinguish pituitary ACTH–dependent Cushing ... ectopic ACTH syndrome (EAS). The usefulness of the paradoxical response of other pituitary hormones including prolactin to CRH remains controversial. Bilateral catheterization of inferior petrosal sinuses can be successful in up to 70% of cases. Prolactin measurements do not have superior ... capability compared with ACTH but may be useful in the differential diagnosis of pituitary–driven from EAS. [more...]

ACTH Deficiency, Higher Doses of Hydrocortisone Replacement, and Radiotherapy Are Independent Predictors of Mortality in Patients with Acromegaly
Journal of Clinical Endocrinology and Metabolism, 10/14/2009

Sherlock M et al. – Radiotherapy and ACTH deficiency are significantly associated with increased mortality in patients with acromegaly. In ACTH ... with increased mortality compared to lower doses. These results have important implications for the treatment of patients with acromegaly and also raise issues as to the optimum hydrocortisone treatment regimens for ACTH–deficient patients. [more...]

Effects of Sucking and Skin-to-Skin Contact on Maternal ACTH and Cortisol Levels During the Second Day Postpartum—Influence of Epidural Analgesia and Oxytocin in the Perinatal Period
Breastfeeding Medicine, 09/24/2009

Handlin L et al. - Breastfeeding is associated with a decrease of ACTH and cortisol levels. Skin-to-skin contact contributes to this effect. ACTH correlated ... inversely with the duration of skin-to-skin contact preceding sucking, suggesting a partial dissociation between the mechanisms regulating ACTH and cortisol release. In addition, medical interventions in connection with birth influence the activity of the hypothalamic-pituitary-adrenal axis 2 days [more...]

Basal, Pulsatile, Entropic (Patterned), and Spiky (Staccato-like) Properties of ACTH Secretion: Impact of Age, Gender, and Body Mass Index
Journal of Clinical Endocrinology and Metabolism, 09/23/2009

Veldhuis JD et al. – Valid comparisons of ultradian ACTH dynamics will require cohorts matched for age, gender, and BMI, conditions hitherto not satisfied in most physiological studies of this axis. [more...]

ACTH-producing pheochromocytoma: Clinical considerations and concise review of the literature
European Journal of Internal Medicine, 10/12/2009

Nijhoff MF et al. – It clearly demonstrates that the relative contributions of clinical, biochemical, and radiological clues in establishing the correct underlying cause of Cushing's syndrome may ... differ considerably between Cushing's disease and Cushing's syndrome due to ectopic overproduction of ACTH. In addition, the literature concerning ACTH–producing pheochromocytomas is reviewed. [more...]

Medical treatment of Cushing's disease: Overview and recent findings
International Journal of General Medicine, 10/21/2009

ACTH) hypersecretion, is the most common etiology of spontaneous excess cortisol production. The majority of pituitary tumors causing Cushing's disease measure <1 cm and the excess morbidity associated with these tumors is mostly due to the effects of elevated, nonsuppressible, ACTH levels leading ... ndash;directed radiation, bilateral adrenalectomy, or medical therapy. This paper addresses current and novel therapies in various stages of development for Cushing’s disease. [more...]

Technical details influence the diagnostic accuracy of the 1 mcg ACTH stimulation test
European Journal of Endocrinology, 10/14/2009

Wade M et al. – The high rate of abnormal results, especially in the afternoon, and loss of ACTH through tubing, suggest that morning testing and minimal tubing should be adopted to avoid an inappropriate ... standardized protocols would facilitate comparison of studies. [more...]

Familial Glucocorticoid Deficiency with a Point Mutation in the ACTH Receptor: A Case Report
Journal of Korean Medical Science, 10/06/2009

Kim CJ et al. – The report a 2 month–old boy of nonconsanguineous parents, presented with hyperpigmentation. Sequence analysis of the ACTH receptor (MC2R) gene showed a homozygous mutation of D103N [more...]

Diagnostic efficacy of midnight cortisol and midnight ACTH in the diagnosis and localisation of Cushings syndrome
Pituitary, 09/01/2009

John M et al. – Classical tests for diagnosis of Cushing’s syndrome (CS) like urine free cortisol and dexamethasone suppression tests have limitations in various clinical ... midnight serum cortisol (SMNC) as a diagnostic test for hypercortisolemia. A single midnight collection could identify all patients with CS and classify the ACTH status at the proposed cut offs. [more...]

Repeatability of the low-dose ACTH test in asthmatic children on inhaled corticosteroids
Acta Pediatrica, 08/31/2009

Gupta A et al. – The results of adrenal function testing in patients on inhaled steroids can have major implications for patient management, making it important to use a test with excellent repeatability [more...]