Glycated Hemoglobin and Risk of Hypertension in the Atherosclerosis Risk in Communities Study
Diabetes Care, 03/30/2012
Bower JK et al. - The authors observed that individuals with elevated HbA1c, even without a prior diabetes diagnosis, are at increased risk of hypertension. glycated hemoglobin (HbA1c) is a known predictor of incident heart disease and stroke. The results suggest that the association of HbA1c with cardiovascular risk may be partially mediated by the development of hypertension.
The authors conducted a prospective analysis of 9,603 middle-aged participants in the Atherosclerosis Risk in Communities Study without hypertension at baseline.
Using Cox proportional hazards models, the authors estimated the association between HbA1c at baseline and incident hypertension by two definitions 1) self-reported hypertension during a maximum of 18 years of follow-up and 2) measured blood pressure or hypertension medication use at clinic visits for a maximum of 9 years of follow-up.
The authors observed 4,800 self-reported and 1,670 visit-based hypertension cases among those without diagnosed diabetes at baseline.
Among those with diagnosed diabetes at baseline, the authors observed 377 self-reported and 119 visit-based hypertension cases.
Higher baseline HbA1c was associated with an increased risk of hypertension in subjects with and without diabetes.
Compared with nondiabetic adults with HbA1c <5.7%, HbA1c in the prediabetic range (5.7–6.4%) was independently associated with incident self-reported hypertension (hazard ratio 1.14 [95% CI 1.06–1.23]) and visit-detected hypertension (1.17 [1.03–1.33]).
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