CRH Acts on CRH-R1 and -R2 to Differentially Modulate the Expression of Large-Conductance Calcium-Activated Potassium Channels in Human Pregnant Myometrium
Xu C et al. – The data suggest that CRH–R1 and CRH–R2 show differential regulation of BKCa expression. These effects mediated by CRH–R1 and CRH–R2 are changed after the onset of labor. This leads us to suggest that CRH may fine–tune myometrial contractility by modulating the expression of BKCa during pregnancy and labor.