Responses to Crh and Dexamethasone in a Large Series of Human Acth-Secreting Pituitary Adenomas in Vitro Reveal Manifold Corticotroph Tumoural Phenotypes
Journal of Neuroendocrinology, 09/01/2011
Giraldi FP et al. – The study of a large series of human ACTH–secreting pituitary tumours in vitro revealed a considerable variability in the responses to CRH and dexamethasone. This finding indicates the existence of multiple corticotroph tumoural phenotypes and may account for the different responses to physiological and pharmacological modulators in vivo.







