6-Thioguanine Inhibition of Parathyroid Hormone-related Protein Expression Is Mediated by GLI2
Anticancer Research, 09/01/2011
Johnson RW et al. – The data indicate that 6–thioguanine (6–TG) regulates parathyroid hormone–related protein (PTHrP) in part through GLI2 transcription, and therefore the clinical use of 6–TG or other guanosine nucleotides may be a viable therapeutic option in tumor types expressing elevated levels of GLI proteins.







