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Clinical Markers Implying the Need for Treatment in Patients with Gestational Diabetes
Endocrine Practice, 08/23/2011
Clayton W et al. – Higher point–of–care hemoglobin A1C (POC A1C), fasting blood glucose (FBG) and BMI levels were associated with the need for medication in patients with GDM. Appropriate treatment decreases the risk of complications from gestational diabetes (GDM).
Methods- POC A1C, FBG and BMI levels at diagnosis and fetal weight at delivery were obtained for patients identified from a prospective patient registry.
- The mean POC A1C (%) and mean FBG (mg/dL) for 67 patients that required medication were higher compared to 71 patients that did not (POC A1C: 5.72±0.45 vs. 5.35±0.46 [p<0.001]; FBG: 97.4±12.3 vs. 86.4±9.5 [p<0.001]).
- The mean BMI results were 35.4±6.4 vs. 30.4± 6.2, respectively.
- There was a modest correlation between POC A1C and FBG (Spearman's rho 0.4, p<0.001) and POC A1C and BMI (Spearman's rho 0.366, p<0.001).
- Maternal POC A1C was not correlated to the fetal weight at delivery (Spearman's rho –0.010, p=0.915).