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Spontaneous Subarachnoid Hemorrhage and Glucose Management
Neurocritical Care , 08/22/2011
Clinical Article
Schmutzhard E et al. – Tight glycemic control was associated with an increased risk for hypoglycemia which was linked to worse outcome.
Methods- Systematic literature search was conducted of English–language articles describing original research on glycemic control in patients with subarachnoid hemorrhage.
- Case reports and case series were excluded.
- Total of 22 publications were selected for this review.
- Among the 17 studies investigating glucose as an outcome predictor, glucose levels during hospitalization were more likely to predict outcome than admission glucose.
- In general, hyperglycemia was linked to worse outcome.
- While insulin therapy in subarachnoid hemorrhage patients was shown to effectively control plasma glucose levels, plasma glucose control was not necessarily reflective of cerebral glucose such that very tight glucose control may lead to neuroglycopenia.
