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Relative utility of 1-h Oral Glucose Tolerance Test as a measure of abnormal glucose homeostasis
Diabetes Research and Clinical Practice, 08/16/2011
Joshipura KJ et al. – The 1–h OGTT correlates well with both fasting glucose and 2–h OGTT and shows similar or higher associations with obesity measures. The 1–h OGTT has potential utility in epidemiologic studies.
Methods- Ninety four overweight/obese individuals free of diabetes and major cardiovascular conditions were included in the analyses.
- The authors adjusted for age, gender, smoking status and physical activity.
- One-h OGTT showed similar partial correlations with fasting glucose and 2-h OGTT (r=0.60 and 0.64 respectively).
- Fasting glucose, fasting insulin and HOMA correlated better with 1-h OGTT (r=0.60, 0.47 and 0.52) than with 2-h OGTT (r=0.50, 0.41, and 0.45).
- BMI and waist circumference also showed stronger correlation with 1-h (r=0.31, 0.29), compared to 2-h OGTT (r=0.16, 0.16) or fasting glucose (r=0.23, 0.22).
- Metabolic syndrome was associated similarly with 1-h and 2-h OGTT.