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Clinical impact of albuminuria in diabetic nephropathy
Clinical and Experimental Nephrology, 08/24/2011
Wada T et al. – Deeper insights into the pathological characteristics as well as the clinical impact of albuminuria on renal and cardiovascular outcome are required.
- Patients suffering from diabetic nephropathy, resulting in end–stage renal failure, are increasing in number.
- The pathophysiology of diabetic nephropathy remains to be fully investigated.
- In the clinical setting, the presence of albuminuria/overt proteinuria and a low glomerular filtration rate may predict poor renal prognosis, but the prognosis of the normoalbuminuric renally insufficient diabetic patient remains controversial.
- In addition to the measurement of urinary albumin excretion, biomarker studies to detect diabetic nephropathy more specifically at the early stage have been performed worldwide.
- There is a growing body of evidence for remission and/or regression of diabetic nephropathy, which may be an indicator for cardiovascular and renal risk reduction.
