Does diabetes mellitus increase the risk of high-grade prostate cancer in patients undergoing radical prostatectomy

Prostate Cancer & Prostatic Diseases, 10/21/2010

The objective was to test the hypothesis that in patients with prostate cancer undergoing radical prostatectomy (RP), diabetic patients are at a higher risk of harboring a high–grade tumor than non–diabetic patients. Authors examined 2060 consecutive men who underwent RP between 2001 and 2009. Of them, 7.1% had type 2 diabetes mellitus (DM). A high–grade tumor was defined as having a Gleason score >=8. In multivariable analyses, DM was an independent predictor of high–grade tumor on biopsy and on final pathological specimen. In patients undergoing RP, those with type 2 DM had a higher risk of harboring a poorly differentiated tumor on final pathological examination.

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