Efficacy of short term adjunctive subantimicrobial dose doxycycline in diabetic patients - randomized study
Oral Diseases , 04/27/2012

Gilowski L et al. – The short–term administration of SDD (subantimicrobial dose doxycycline) gives significant benefit at tooth sites with moderate disease (probing depth?4mm) when compared to scaling and root planing (SRP) alone in patients with diabetes and chronic periodontitis.

• Thirty-four patients with CP and type 2 diabetes mellitus were included in the placebo-controlled, double-blind study.
• After scaling and root planing (SRP) patients were randomly assigned to two groups, receiving either SDD or placebo bid for 3 months.
• The probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP) approximal plaque index (API), glycated hemoglobin (HbA1c) level were recorded and GCF (gingival crevicular fluid) samples were collected at baseline and after three months therapy for the estimation of matrix metalloproteinase-8 levels.

• CAL, PD and BOP improved significantly in both groups after therapy (P< 0.05).
• The statistically significant difference between the two groups after the therapy was observed only in probing depth in tooth sites with initial PD≥4 mm (SRP+placebo: 3.41 ± 0.6 mm vs. SRP+SDD: 2.92 ± 0.5 mm, P<0.05).
• GCF matrix metalloproteinase-8 levels were significantly reduced only in SRP+SDD group (P< 0.01).
• There were no changes in HbA1c levels after therapy.