The Value of Admission HbA1c Level in Diabetic Patients With Acute Coronary Syndrome
Clinical Cardiology, 07/05/2011

Chan CY et al. – This study suggests that HbA1c levels before admission are not associated with short–term cardiovascular outcome in diabetic patients subsequently admitted with acute coronary syndrome (ACS).

• Authors conducted a retrospective study with prospective follow–up in 317 diabetic patients with ACS.
• Patients were stratified into 2 groups based on HbA1c level, checked within 8 weeks of the index admission (optimal control group, HbA1c ≤7%; suboptimal control group, HbA1c >7%).
• All patients were followed up prospectively for major adverse cardiovascular events (MACE) and mortality for 6 months.
• Short–term clinical outcomes were also compared between the 2 study groups.

• In this cohort, 27.4%, 46.4%, and 26.2% patients had unstable angina, non–ST–segment elevation myocardial infarction, and ST–segment elevation myocardial infarction, respectively.
• In–hospital mortality was similar in both HbA1c groups (3.37% vs 2.88%, P = 0.803).
• Six–month MACE was also similar (26.40% vs 26.47%, P = 0.919).
• All–cause mortality, cardiovascular mortality, symptom–driven revascularization, rehospitalization for angina, and hospitalization for heart failure were also similar in both groups.
• The hazard ratios for 6–month MACE and individual endpoints were also similar in both groups.