Parenteral vitamin D improves insulin sensitivity
As reported in Swiss Medical Weekly, supplemental vitamin D3 (300,000 IU im) in patients (n=55) with T2DM of > 10 y duration resulted in a 12.8% decrease in HOMA-IR at 6 months compared to an increase of 10% in patients who received placebo.
Low vitamin D levels increase risk of GDM
As reported in Acta Diabetologica, the OR for developing gestational diabetes mellitus was 1.48 for each 1 SD decrease in the 25OHD level. A decrease in 25OHD was also shown to be associated with increased insulin resistance in the second trimester.
TNFR1 predicts all-cause mortality in diabetic kidney disease
As reported in Diabetes Care, type 2 diabetics (n=522) with diabetic kidney disease (eGFR< 60 or urinary albumin-to-creatinine ratio > 30 mg/mmol) with TNFR1 levels in the highest quartile were at increased risk of all-cause mortality compared to diabetics with TNFR1 levels in the lowest quartile (aHR = 2.98). One hundred ninety-six deaths occurred in 48 months of follow-up.