1Differential Effects of Adiposity on Pharmacodynamics of Basal Insulins NPH, Glargine, and Detemir in Type 2 DiabetesDiabetes Care  Full Text
2Benefit of early statin therapy in patients with acute myocardial infarction who have extremely low low-density lipoprotein cholesterolJACC - Journal of the American College of Cardiology  Full Text  Clinical Article
3Transcutaneous Bilirubin in Exclusively Breastfed Healthy Term Newborns Up to 12 Days of LifePediatrics  Full Text
4Reduced Prevalence of Diabetes Ketoacidosis at Diagnosis of Type 1 Diabetes in Young Children Participating in Longitudinal Follow-UpDiabetes Care  Full Text
5Incidence and Age-Specific Presentation of Restrictive Eating Disorders in Children: A Canadian Paediatric Surveillance Program Study Archives of Pediatrics and Adolescent Medicine  Full Text
6The I405V and Taq1B polymorphisms of the CETP gene differentially affect sub-clinical carotid atherosclerosisLipids in Health and Disease  Full Text
7Cluster randomized controlled trial of a peer support program for people with diabetes: study protocol for the Australasian peers for progress studyBMC Public Health  Full Text
8Factors influencing participant enrolment in a diabetes prevention program in general practice: lessons from the Sydney diabetes prevention programBMC Public Health  Full Text
9The high prevalence of chronic kidney disease-mineral bone disorders: A hospital-based cross-sectional studyIndian Journal of Nephrology  Full Text  Clinical Article
10Leisure time activities in adolescence in the presence of susceptibility genes for obesity: risk or resilience against overweight in adulthood? The HUNT studyBMC Public Health  Full Text
1WHO calls for worldwide use of "smart" syringesWHO news
2Joslin scientists find direct link between insulin resistance in the brain and behavioral disordersJoslin Diabetes Center News
3‘Feeding and fasting’ hormone adropin can improve insulin actionSaint Louis University Health News
4Interaction of estrogen receptor and coactivators seen for first timeBaylor College of Medicine News
5SLU researcher prevents type I diabetes in labSaint Louis University Health News
6A new stem cell advanceHarvard Gazette - Health News
7Synthetic biology breakthrough leads to cheaper statin productionThe University of Manchester News
8NYU study successfully screens for diabetes at dental visits using oral bloodNew York University News
9Renewed call in Lancet for Governments to get smart to curb obesityUniversity of Otago News
10Soft drink tax could improve health of the nation TopMonash University News

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Vildegliptin superior to glimepiride when added to metformin

As reported in Metabolism, addition of vildegliptin (50 mg bid) to metformin in T2DM patients inadequately controlled on metformin alone was superior to the addition of glimepiride (2 mg tid) to metformin. Patients on the vildegliptin + metformin regimen lost more weight, had an improved lipid profile, had increased insulin sensitivity, and decreased post-prandial lipemia and insulinemia compared to patients on the glimepiride + metformin regimen.

TNFR1 predicts all-cause mortality in diabetic kidney disease

As reported in Diabetes Care, type 2 diabetics (n=522) with diabetic kidney disease (eGFR< 60 or urinary albumin-to-creatinine ratio > 30 mg/mmol) with TNFR1 levels in the highest quartile were at increased risk of all-cause mortality compared to diabetics with TNFR1 levels in the lowest quartile (aHR = 2.98). One hundred ninety-six deaths occurred in 48 months of follow-up.

Parenteral vitamin D improves insulin sensitivity

As reported in Swiss Medical Weekly, supplemental vitamin D3 (300,000 IU im) in patients (n=55) with T2DM of > 10 y duration resulted in a 12.8% decrease in HOMA-IR at 6 months compared to an increase of 10% in patients who received placebo.

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Clinical Pearl from Smartest DocInsulin resistance worsens during maintenance therapy for pediatric acute lymphoblastic leukemia.

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Clinical Pearl from Smartest DocThiazolidinediones may promote fat mass gain.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List