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Our Endocrinology medical editors have ranked and organized the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the latest endocrine news literature as it is published.

Exclusive endocrine content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.

Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

1 Differential Effects of Adiposity on Pharmacodynamics of Basal Insulins NPH, Glargine, and Detemir in Type 2 Diabetes Full Text Diabetes Care, October 8, 2012 Original Publication Date: October 7, 2011

2 Benefit of early statin therapy in patients with acute myocardial infarction who have extremely low low-density lipoprotein cholesterol Full Text JACC - Journal of the American College of Cardiology, October 8, 2012 Original Publication Date: October 7, 2011    Clinical Article

3 Transcutaneous Bilirubin in Exclusively Breastfed Healthy Term Newborns Up to 12 Days of Life Full Text Pediatrics, October 8, 2012 Original Publication Date: October 7, 2011

4 Reduced Prevalence of Diabetes Ketoacidosis at Diagnosis of Type 1 Diabetes in Young Children Participating in Longitudinal Follow-Up Full Text Diabetes Care, October 8, 2012 Original Publication Date: October 7, 2011

5 Incidence and Age-Specific Presentation of Restrictive Eating Disorders in Children: A Canadian Paediatric Surveillance Program Study Full Text Archives of Pediatrics and Adolescent Medicine, October 8, 2012 Original Publication Date: October 7, 2011

6 The I405V and Taq1B polymorphisms of the CETP gene differentially affect sub-clinical carotid atherosclerosis Full Text Lipids in Health and Disease, October 8, 2012

7 Cluster randomized controlled trial of a peer support program for people with diabetes: study protocol for the Australasian peers for progress study Full Text BMC Public Health, October 8, 2012

8 Factors influencing participant enrolment in a diabetes prevention program in general practice: lessons from the Sydney diabetes prevention program Full Text BMC Public Health, October 8, 2012

9 The high prevalence of chronic kidney disease-mineral bone disorders: A hospital-based cross-sectional study Full Text Indian Journal of Nephrology, October 8, 2012    Clinical Article

10 Leisure time activities in adolescence in the presence of susceptibility genes for obesity: risk or resilience against overweight in adulthood? The HUNT study Full Text BMC Public Health, October 8, 2012

11 Predictors of overweight and obesity in adult women in Nairobi Province, Kenya Full Text BMC Public Health, October 8, 2012

12 Risk of Breast Cancer After Onset of Type 2 Diabetes: Evidence of detection bias in postmenopausal women Full Text Diabetes Care, October 7, 2012 Original Publication Date: October 6, 2011

13 Diabetes Antibody Standardization Program: First evaluation of assays for autoantibodies to IA-2{beta} Full Text Diabetes Care, October 7, 2012 Original Publication Date: October 6, 2011

14 Sex Hormone-Binding Globulin, But Not Testosterone, Is Associated Prospectively and Independently With Incident Metabolic Syndrome in Men: The Framingham Heart Study Full Text Diabetes Care, October 7, 2012 Original Publication Date: October 6, 2011

15 Prevalence of Asthma and Its Association With Glycemic Control Among Youth With Diabetes Full Text Pediatrics, October 7, 2012 Original Publication Date: October 6, 2011

16 Impact of Maternal Diabetes Mellitus on Mortality and Morbidity of Preterm Infants (24–33 Weeks' Gestation) Full Text Pediatrics, October 7, 2012 Original Publication Date: October 6, 2011

17 Long-Term Metabolic and Immunological Follow-Up of Nonimmunosuppressed Patients With Type 1 Diabetes Treated With Microencapsulated Islet Allografts Full Text Diabetes Care, October 7, 2012 Original Publication Date: October 6, 2011

18 The LiP (Lifestyle in Pregnancy) Study: A randomized controlled trial of lifestyle intervention in 360 obese pregnant women Full Text Diabetes Care, October 7, 2012 Original Publication Date: October 6, 2011

19 Pulmonary Resection for Metastatic Adrenocortical Carcinoma: The National Cancer Institute Experience Full Text Annals of Thoracic Surgery, October 7, 2012 Original Publication Date: October 6, 2011

20 Prospective Associations of Vitamin D With {beta}-Cell Function and Glycemia: The Prospective Metabolism and Islet Cell Evaluation (PROMISE) Cohort Study Full Text Diabetes, October 5, 2012 Original Publication Date: October 4, 2011

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Clinical Pearls in Endocrinology

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Highlights in Endocrinology

Regulatory protein identified in T1DM

As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.

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Statins increase risk of DM in postmenopausal women

As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up

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Determining the basal insulin dosage in T2DM

Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.

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