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Endocrinology - Fetal Development News & Articles
MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
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Articles
Latest Full Text Articles (40) Focus on Atherosclerosis721 Increased LDL cholesterol and CRP in infants of mothers with type 1 diabetes Diabetes/Metabolism Research and Reviews, June 18, 2008
722 Maternal hormones linking maternal body mass index and dietary intake to birth weight Full Text American Journal of Clinical Nutrition, June 11, 2008
723 Maternal smoking very early in pregnancy is related to child overweight at age 5–7 y Full Text American Journal of Clinical Nutrition, June 10, 2008
724 Nicotine and brain development Birth Defects Research Part A: Clinical and Molecular Teratology, June 9, 2008
725 Pathophysiology of insulin resistance in subjects born small for gestational age Best Practice & Research Clinical Endocrinology & Metabolism, June 6, 2008
726 Epigenetics in Silver-Russell syndrome Best Practice & Research Clinical Endocrinology & Metabolism, June 6, 2008
727 Hedgehog Serves as a Mitogen and Survival Factor During Embryonic Stem Cell Neurogenesis Full Text Stem Cells, June 6, 2008
728 Foetal death following lactic acidosis induced by ethanol, cocaine and metformin Practical Diabetes, June 4, 2008
729 Role of Adiponectin in Matching of Fetal and Placental Weight in Mothers With Type 1 Diabetes Full Text Diabetes Care, May 30, 2008
730 The Diabetic Phenotype in HNF4A Mutation Carriers Is Moderated By the Expression of HNF4A Isoforms From the P1 Promoter During Fetal Development Full Text Diabetes, May 29, 2008
731 The Relationship Between Neonatal Developmental Dysplasia of the Hip and Maternal Hyperthyroidism Journal of Pediatric Orthopaedics , May 29, 2008
732 Circulating and Placental Endoglin Concentrations in Pregnancies Complicated by Intrauterine Growth Restriction and Preeclampsia Placenta, May 28, 2008
733 Transcription factor expression in the developing human fetal endocrine pancreas Diabetologia - Clinical and Experimental Diabetes and Metabolism, May 23, 2008
734 The effect of birthweight upon insulin resistance and associated cardiovascular risk factors in adolescence is not explained by fetal growth velocity in the third trimester as measured by repeated ultrasound fetometry Diabetologia - Clinical and Experimental Diabetes and Metabolism, May 23, 2008
735 Haploinsufficiency at GCK gene is not a frequent event in MODY2 patients Clinical Endocrinology, May 19, 2008
736 Is insulin lispro safe in pregnant women: Does it cause any adverse outcomes on infants or mothers Diabetes Research and Clinical Practice, May 16, 2008
737 Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet–Biedl syndrome Full Text Proceedings of the National Academy of Sciences of the United States of America, May 9, 2008
738 Gender Specificity of Body Adiposity and Circulating Adiponectin, Visfatin, Insulin and IGF-I at Term Birth: Relation to Prenatal Growth Full Text Journal of Clinical Endocrinology and Metabolism, May 7, 2008
739 Individualized Norms of Optimal Fetal Growth Full Text Obstetrics and Gynecology, May 6, 2008
740 High molecular weight multimer complexes and vascular expression contribute to high adiponectin in the fetus Full Text Journal of Clinical Endocrinology and Metabolism, May 2, 2008
Clinical Pearls in Endocrinology
- Pioglitazone can reduce the risk of conversion of impaired glucose tolerance to type 2 diabetes mellitus by 72%, but it was also associated with significant weight gain and edema
- The most commonly reported adverse event associated with Janumet in the treatment of type 2 diabetes is diarrhea, followed by upper respiratory tract infection and headache
- Maturity-onset diabetes of the young (MODY)3 can be treated with sulfonylureas with excellent results for decades
Highlights in Endocrinology
Regulatory protein identified in T1DM
As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.
Read the article summaryStatins increase risk of DM in postmenopausal women
As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up
Read the article summaryDetermining the basal insulin dosage in T2DM
Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.
Read the article summaryMost Popular Endocrinology Articles
Last month's top read Top Articles of 20121 Epigenetics of gestational diabetes mellitus and offspring health: the time for action is in early stages of life Molecular Human Reproduction, April 2, 2013
2 Treatment with the long-acting insulin analogues detemir or glargine during pregnancy in women with type 1 diabetes: comparison of glycaemic control and pregnancy outcome The Journal of Maternal-Fetal and Neonatal Medicine, April 3, 2013
3 Parental eating behavior traits are related to offspring BMI in the Quebec Family Study International Journal of Obesity, February 13, 2013
4 The diagnostic criteria for gestational diabetes: to change or not to change? American Journal of Obstetrics and Gynecology, April 15, 2013
5 Low-Carbohydrate Diet for the Treatment of Gestational Diabetes: A randomized controlled trial Diabetes Care, April 9, 2013
6 Childhood cognitive development after fetal growth restriction Ultrasound in Obstetrics & Gynecology, April 2, 2013
7 The Molecular Mechanisms of Offspring Effects from Obese Pregnancy Obesity Facts, April 4, 2013 Review Article
8 Gestational diabetes, pre-pregnancy obesity and pregnancy weight gain in relation to excess fetal growth: variations by race/ethnicity Diabetologia - Clinical and Experimental Diabetes and Metabolism, April 10, 2013 Review Article
9 Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring International Journal of Obesity, April 24, 2013 Review Article
10 Placental regulation of fetal nutrient supply Current Opinion in Clinical Nutrition & Metabolic Care, April 12, 2013 Review Article
11 Differences in the association between maternal serum homocysteine and ADMA levels in women with pregnancies complicated by preeclampsia and/or intrauterine growth restriction Hypertension in Pregnancy, March 29, 2013
12 Placental weight mediates the effects of prenatal factors on fetal growth: the extent differs by preterm status Obesity, April 18, 2013 Review Article
13 Fetal metabolic programming and epigenetic modifications: a systems biology approach Pediatric Research, March 13, 2013 Review Article
14 Effect of reducing the n-6/n-3 fatty acid ratio on the maternal and fetal leptin axis in relation to infant body composition Obesity, April 18, 2013
15 A role for mitochondria in gestational diabetes mellitus Gynecological Endocrinology, March 19, 2013
16 Risk of Childhood Obesity in the Toddler Offspring of Mothers With Gestational Diabetes Obstetrics and Gynecology, April 26, 2013 Free full text
17 Interventions designed to limit gestational weight gain: a systematic review of theory and meta-analysis of intervention components Obesity Reviews, April 17, 2013 Evidence Based Medicine Review Article
18 Risk of Childhood Obesity in the Toddler Offspring of Mothers With Gestational Diabetes Obstetrics and Gynecology, April 23, 2013
19 The obstetric syndromes: clinical relevance of placental hormones Expert Review of Endocrinology & Metabolism, March 6, 2013 Review Article
20 Influence of insulin sensitivity and secretion on glycated albumin and hemoglobin A1c in pregnant women with gestational diabetes mellitus International Journal of Gynecology & Obstetrics, April 8, 2013
Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetes more
Other Topics in Endocrinology
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