Endocrinology - Fetal Development News & Articles

MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.

Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.

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181 Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits Diabetologia - Clinical and Experimental Diabetes and Metabolism, March 12, 2012

182 Maternal fatty acid status during pregnancy and risk of type 1 diabetes in the offspring Diabetes/Metabolism Research and Reviews, March 7, 2012

183 Gestational diabetes and cardiovascular risk factors in the offspring: Results from a cross-sectional study Diabetic Medicine, March 6, 2012

184 Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes Full Text Diabetes, February 28, 2012

185 Abundance of Circulating Preadipocyte Factor-1 in Early Life Full Text Diabetes Care, February 28, 2012

186 Embryology and Imaging Review of Aortic Arch Anomalies Journal of Thoracic Imaging, February 22, 2012

187 Differential Ontogenetic Patterns of in vitro Desensitization to GHRH in Fetal and Neonatal Anterior Pituitary Neuroendocrinology, February 15, 2012

188 Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes Diabetologia - Clinical and Experimental Diabetes and Metabolism, February 8, 2012

189 The association of apolipoprotein E polymorphism and lipid levels in children with a family history of premature coronary artery disease Journal of Clinical Lipidology, February 2, 2012

190 Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-aged subjects predisposed to familial longevity American Journal of Physiology - Endocrinology and Metabolism, January 26, 2012

191 Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells Full Text The Journal of Clinical Investigation, January 25, 2012

192 Effect of maternal age and growth on placental nutrient transport: potential mechanisms for teenagers' predisposition to small-for-gestational-age birth American Journal of Physiology - Endocrinology and Metabolism, January 24, 2012

193 The growth hormone receptor gene deleted for exon three (iGHRd3/i) polymorphism is associated with birth and placental weight Clinical Endocrinology, January 19, 2012

194 Differential Regulation of Glucose Transporters Mediated by CRH Receptor Type 1 and Type 2 in Human Placental Trophoblasts Endocrinology, January 19, 2012

195 The association between in utero hyperinsulinemia and adolescent arterial stiffness Diabetes Research and Clinical Practice, January 16, 2012

196 Atypical Fetal Response to the Mother's Voice in Diabetic Compared With Overweight Pregnancies Journal of Developmental and Behavioral Pediatrics, January 12, 2012

197 Strong Parent-Offspring Association of Metabolic Syndrome in Korean Families Full Text Diabetes Care, January 5, 2012

198 Does maternal body mass index during pregnancy influence risk of schizophrenia in the adult offspring Obesity Reviews, December 29, 2011

199 Relationship between body mass index of offspring and maternal smoking during pregnancy International Journal of Obesity, December 21, 2011

200 Maternal Serum Levels of 25-Hydroxy-Vitamin D During Pregnancy and Risk of Type 1 Diabetes in the Offspring Full Text Diabetes, December 20, 2011
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Clinical Pearls in Endocrinology

Pioglitazone can reduce the risk of conversion of impaired glucose tolerance to type 2 diabetes mellitus by 72%, but it was also associated with significant weight gain and edema
The most commonly reported adverse event associated with Janumet in the treatment of type 2 diabetes is diarrhea, followed by upper respiratory tract infection and headache
Maturity-onset diabetes of the young (MODY)3 can be treated with sulfonylureas with excellent results for decades

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Highlights in Endocrinology

Regulatory protein identified in T1DM

As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.

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Statins increase risk of DM in postmenopausal women

As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up

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Determining the basal insulin dosage in T2DM

Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.

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Most Popular Endocrinology Articles

Last month's top read Top Articles of 2012

1 Epigenetics of gestational diabetes mellitus and offspring health: the time for action is in early stages of life Molecular Human Reproduction, April 2, 2013

2 Treatment with the long-acting insulin analogues detemir or glargine during pregnancy in women with type 1 diabetes: comparison of glycaemic control and pregnancy outcome The Journal of Maternal-Fetal and Neonatal Medicine, April 3, 2013

3 Parental eating behavior traits are related to offspring BMI in the Quebec Family Study International Journal of Obesity, February 13, 2013

4 The diagnostic criteria for gestational diabetes: to change or not to change? American Journal of Obstetrics and Gynecology, April 15, 2013

5 Low-Carbohydrate Diet for the Treatment of Gestational Diabetes: A randomized controlled trial Diabetes Care, April 9, 2013

6 Childhood cognitive development after fetal growth restriction Ultrasound in Obstetrics & Gynecology, April 2, 2013

7 The Molecular Mechanisms of Offspring Effects from Obese Pregnancy Obesity Facts, April 4, 2013 Review Article

8 Gestational diabetes, pre-pregnancy obesity and pregnancy weight gain in relation to excess fetal growth: variations by race/ethnicity Diabetologia - Clinical and Experimental Diabetes and Metabolism, April 10, 2013 Review Article

9 Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring International Journal of Obesity, April 24, 2013 Review Article

10 Placental regulation of fetal nutrient supply Current Opinion in Clinical Nutrition & Metabolic Care, April 12, 2013 Review Article

11 Differences in the association between maternal serum homocysteine and ADMA levels in women with pregnancies complicated by preeclampsia and/or intrauterine growth restriction Hypertension in Pregnancy, March 29, 2013

12 Placental weight mediates the effects of prenatal factors on fetal growth: the extent differs by preterm status Obesity, April 18, 2013 Review Article

13 Fetal metabolic programming and epigenetic modifications: a systems biology approach Pediatric Research, March 13, 2013 Review Article

14 Effect of reducing the n-6/n-3 fatty acid ratio on the maternal and fetal leptin axis in relation to infant body composition Obesity, April 18, 2013

15 A role for mitochondria in gestational diabetes mellitus Gynecological Endocrinology, March 19, 2013

16 Risk of Childhood Obesity in the Toddler Offspring of Mothers With Gestational Diabetes Obstetrics and Gynecology, April 26, 2013 Free full text

17 Interventions designed to limit gestational weight gain: a systematic review of theory and meta-analysis of intervention components Obesity Reviews, April 17, 2013 Evidence Based Medicine Review Article

18 Risk of Childhood Obesity in the Toddler Offspring of Mothers With Gestational Diabetes Obstetrics and Gynecology, April 23, 2013

19 The obstetric syndromes: clinical relevance of placental hormones Expert Review of Endocrinology & Metabolism, March 6, 2013 Review Article

20 Influence of insulin sensitivity and secretion on glycated albumin and hemoglobin A1c in pregnant women with gestational diabetes mellitus International Journal of Gynecology & Obstetrics, April 8, 2013

Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetes more

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Endocrinology - Fetal Development News & Articles

Articles

Clinical Pearls in Endocrinology

Highlights in Endocrinology

Regulatory protein identified in T1DM

Statins increase risk of DM in postmenopausal women

Determining the basal insulin dosage in T2DM

Most Popular Endocrinology Articles

Other Topics in Endocrinology