MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
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1 Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (getgoal-x) Diabetes Care, May 24, 2013 Clinical Article
2 Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomised, double-blind, placebo-controlled study The Lancet, May 23, 2013 Evidence Based Medicine Clinical Article
3 Efficacy and safety of carisbamate in patients with diabetic neuropathy or postherpetic neuralgia: results from 3 randomized, double-blind placebo-controlled trials Pain Practice, May 23, 2013 Clinical Article
4 Are users of sulfonylureas at the time of an acute coronary syndrome at risk of poorer outcomes? Diabetes, Obesity and Metabolism, May 23, 2013 Clinical Article
5 The place of medical treatment of acromegaly: current status and perspectives Expert Opinion on Pharmacotherapy, May 23, 2013 Review Article
6 Efficacy of cinacalcet with low-dose vitamin D in incident haemodialysis subjects with secondary hyperparathyroidism Nephrology Dialysis Transplantation, May 22, 2013 Clinical Article
7 The effectiveness of teriparatide in the clinical practice-attenuation of the bone mineral density outcome by increasing age and bisphosphonate pretreatment Annals of Medicine, May 22, 2013 Evidence Based Medicine Clinical Article
8 Liraglutide suppresses postprandial triglyceride and apolipoprotein B48 elevations after a fat-rich meal in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, crossover trial Diabetes, Obesity and Metabolism, May 20, 2013 Clinical Article
9 First human dose-escalation study with remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), in healthy subjects and in subjects with type 2 diabetes mellitus Full Text BMC Pharmacology & Toxicology, May 20, 2013 Clinical Article
10 Dexamethasone for the Prevention of Recurrent Laryngeal Nerve Palsy and Other Complications After Thyroid Surgery JAMA Otolaryngology—Head & Neck Surgery, May 17, 2013 Clinical Article
11 Effect of thiazolidinediones and insulin on cognitive outcomes in ACCORD-MIND Journal of Diabetes and its Complications, May 16, 2013 Clinical Article
12 Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial The Lancet, May 16, 2013 Clinical Article
13 Effects of co-administration of candesartan with pioglitazone on inflammatory parameters in hypertensive patients with type 2 diabetes mellitus: a preliminary report Full Text Cardiovascular Diabetology, May 15, 2013 Clinical Article
14 Sulphonylureas and risk of cardiovascular disease: systematic review and meta-analysis Diabetic Medicine, May 15, 2013 Evidence Based Medicine Review Article Clinical Article
15 Combination therapy of dipeptidyl peptidase-4 inhibitors and metformin in type 2 diabetes: Rationale and evidence Diabetes, Obesity and Metabolism, May 15, 2013 Clinical Article
16 Effects of Low-Dose Prednisolone on Hepatic and Peripheral Insulin Sensitivity, Insulin Secretion, and Abdominal Adiposity in Patients With Inflammatory Rheumatologic Disease Diabetes Care, May 15, 2013 Review Article
17 Dapagliflozin a Glucose-Regulating Drug With Diuretic Properties in Subjects With Type 2 Diabetes Diabetes, Obesity and Metabolism, May 14, 2013 Clinical Article
18 The effect of topiramate on weight loss in patients with type 2 diabetes Journal of Research in Medical Sciences, May 14, 2013 Evidence Based Medicine Clinical Article
19 Mortality outcomes of different sulfonylurea drugs. The results of a 14-year cohort study of type 2 diabetic patients European Journal of Endocrinology, May 13, 2013 Clinical Article
20 Sulphonylurea monotherapy for patients with type 2 diabetes mellitus Cochrane Reviews, May 13, 2013 Evidence Based Medicine Clinical Article
As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.
Read the article summaryAs reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up
Read the article summaryAnthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.
Read the article summary1 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, April 9, 2013
2 Trends in selection and timing of first-line pharmacotherapy in older patients with Type 2 diabetes diagnosed between 1994 and 2006 Diabetic Medicine, April 18, 2013
3 Effects of patient-tailored atorvastatin therapy on ameliorating the levels of atherogenic lipids and inflammation beyond lowering low-density lipoprotein cholesterol in patients with type 2 diabetes Journal of Diabetes Investigation, April 3, 2013 Review Article
4 Hormonal versus non-hormonal contraceptives in women with diabetes mellitus type 1 and 2 Cochrane Reviews, April 1, 2013 Review Article
5 Who Needs an Artificial Pancreas? Journal of Diabetes, April 25, 2013
6 Safety and Effect of Very Low Levels of Low-Density Lipoprotein Cholesterol on Cardiovascular Events The American Journal of Cardiology, April 4, 2013
7 Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics Drug Design, Development and Therapy, April 16, 2013 Free full text
8 Determinants of Maternal Triglycerides in Women With Gestational Diabetes Mellitus in the Metformin in Gestational Diabetes (MiG) Study Diabetes Care, March 8, 2013
9 Effect of sulfonylurea dose escalation on hemoglobin A1c in Veterans Affairs patients with type 2 diabetes Acta Diabetologia, April 26, 2013 Review Article
10 The Effect of Chronic Twice Daily Exenatide Treatment on β-cell Function in New Onset Type 2 Diabetes Clinical Endocrinology, March 15, 2013
11 Effects of pioglitazone versus glimepiride exposure on hepatocellular fat content in type 2 diabetes Diabetes, Obesity and Metabolism, April 10, 2013
12 Telmisartan as a metabolic sartan: The first meta-analysis of randomized controlled trials in metabolic syndrome Journal of the American Society of Hypertension, April 24, 2013
13 Validation of a Novel Method for Determining the Renal Threshold for Glucose Excretion in Untreated and Canagliflozin-treated Subjects With Type 2 Diabetes Mellitus Journal of Clinical Endocrinology and Metabolism, April 15, 2013
14 Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: A randomized clinical trial Clinical Nutrition, March 26, 2013
15 Desiccated Thyroid Extract Compared With Levothyroxine in the Treatment of Hypothyroidism: A Randomized, Double-Blind, Crossover Study Journal of Clinical Endocrinology and Metabolism, March 29, 2013
16 Effect of insulin degludec versus sitagliptin in patients with type 2 diabetes uncontrolled on oral antidiabetic agents Diabetes, Obesity and Metabolism, April 12, 2013
17 Higher doses of cabergoline further improve metabolic parameters in patients with prolactinoma regardless of the degree of reduction in prolactin levels Clinical Endocrinology, March 29, 2013
18 Metformin Inhibits Goitrogenous Effects of Type 2 Diabetes European Journal of Endocrinology, April 11, 2013
19 Over-the-Counter-Drug-Induced Thyroid Disorders Endocrine Practice, March 26, 2013 Free full text
20 Drug Prescription Patterns in Patients With Addison's Disease: A Swedish Population-Based Cohort Study Journal of Clinical Endocrinology and Metabolism, April 2, 2013
Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetes more
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