Endocrinology - Pharmacology/kinetics News & Articles

MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.

Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (2) Full Text Articles (199) Focus on Basic Science/Genetics

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

121 Expectations about Insulin Therapy, Perceived Insulin Delivery System Social Acceptability, and Insulin Treatment Satisfaction Contribute to Decreases in Insulin Therapy Self-Efficacy in Patients with Type 2 Diabetes after 36 Weeks of Insulin Therapy Journal of Diabetes, March 14, 2013 Clinical Article

122 Superior glycaemic control with once-daily insulin degludec/insulin aspart vs. insulin glargine in Japanese adults with type 2 diabetes inadequately controlled with oral drugs: A randomised, controlled phase 3 trial Diabetes, Obesity and Metabolism, March 14, 2013 Clinical Article

123 Preferences for Medication Attributes Among Patients with Type 2 Diabetes Mellitus in the United Kingdom Diabetes, Obesity and Metabolism, March 14, 2013 Clinical Article

124 Bisphosphonate treatment may reduce osteoporosis risk in female cancer patients with morphine use: a population-based nested case-control study Osteoporosis International, March 14, 2013 Clinical Article

125 Letrozole usage adjuvant to gonadotropins for ovulation induction for patients with clomiphene citrate failure Archives of Gynecology and Obstetrics, March 14, 2013 Clinical Article

126 The use of U-500 regular insulin in the management of patients with obesity and insulin resistance Diabetes, Obesity and Metabolism, March 13, 2013 Clinical Article

127 Combination therapy with naltrexone and bupropion for obesity reduces total and visceral adiposity Diabetes, Obesity and Metabolism, March 13, 2013 Clinical Article

128 Interactive effects of fitness and statin treatment on mortality risk in veterans with dyslipidaemia: a cohort study The Lancet, March 13, 2013 Clinical Article

129 Severe Hypoglycemia from Helicobacter Pylori Triple-Drug Therapy and Insulin Detemir Drug Interaction Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, March 13, 2013

130 Colesevelam improved lipoprotein particle subclasses in patients with prediabetes and primary hyperlipidaemia Diabetes & Vascular Disease Research, March 12, 2013 Clinical Article

131 The need for better insulin therapy Diabetes, Obesity and Metabolism, March 12, 2013 Review Article

132 Methods to enhance delivery of prandial insulin and basal-prandial insulin Diabetes, Obesity and Metabolism, March 12, 2013 Review Article

133 Mifepristone for Management of Cushings Syndrome Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, March 12, 2013 Clinical Article

134 Efficacy and safety of lixisenatide in the treatment of Type 2 diabetes mellitus: a review of Phase III clinical data Expert Review of Endocrinology & Metabolism, March 11, 2013 Review Article Clinical Article

135 Efficacy, safety and dose-response relationship of teneligliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus Diabetes, Obesity and Metabolism, March 11, 2013 Clinical Article

136 Determinants of Maternal Triglycerides in Women With Gestational Diabetes Mellitus in the Metformin in Gestational Diabetes (MiG) Study Diabetes Care, March 8, 2013 Clinical Article

137 Dose-ranging study with the glucokinase activator AZD1656 in patients with type 2 diabetes mellitus on metformin Diabetes, Obesity and Metabolism, March 8, 2013 Clinical Article

138 Efficacy and Safety of Canagliflozin in Subjects With Type 2 Diabetes And Chronic Kidney Disease Diabetes, Obesity and Metabolism, March 8, 2013 Clinical Article

139 Iron and Diabetes Risk Cell Metabolism, March 8, 2013 Clinical Article

140 Endocrine Side Effects Induced by Immune Checkpoint Inhibitors Journal of Clinical Endocrinology and Metabolism, March 8, 2013 Review Article

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Clinical Pearls in Endocrinology

Pioglitazone can reduce the risk of conversion of impaired glucose tolerance to type 2 diabetes mellitus by 72%, but it was also associated with significant weight gain and edema
The most commonly reported adverse event associated with Janumet in the treatment of type 2 diabetes is diarrhea, followed by upper respiratory tract infection and headache
Maturity-onset diabetes of the young (MODY)3 can be treated with sulfonylureas with excellent results for decades

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Highlights in Endocrinology

Regulatory protein identified in T1DM

As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.

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Statins increase risk of DM in postmenopausal women

As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up

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Determining the basal insulin dosage in T2DM

Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.

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Most Popular Endocrinology Articles

Last month's top read Top Articles of 2012

1 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, April 9, 2013

2 Trends in selection and timing of first-line pharmacotherapy in older patients with Type 2 diabetes diagnosed between 1994 and 2006 Diabetic Medicine, April 18, 2013

3 Effects of patient-tailored atorvastatin therapy on ameliorating the levels of atherogenic lipids and inflammation beyond lowering low-density lipoprotein cholesterol in patients with type 2 diabetes Journal of Diabetes Investigation, April 3, 2013 Review Article

4 Hormonal versus non-hormonal contraceptives in women with diabetes mellitus type 1 and 2 Cochrane Reviews, April 1, 2013 Review Article

5 Who Needs an Artificial Pancreas? Journal of Diabetes, April 25, 2013

6 Safety and Effect of Very Low Levels of Low-Density Lipoprotein Cholesterol on Cardiovascular Events The American Journal of Cardiology, April 4, 2013

7 Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics Drug Design, Development and Therapy, April 16, 2013 Free full text

8 Determinants of Maternal Triglycerides in Women With Gestational Diabetes Mellitus in the Metformin in Gestational Diabetes (MiG) Study Diabetes Care, March 8, 2013

9 Effect of sulfonylurea dose escalation on hemoglobin A1c in Veterans Affairs patients with type 2 diabetes Acta Diabetologia, April 26, 2013 Review Article

10 The Effect of Chronic Twice Daily Exenatide Treatment on β-cell Function in New Onset Type 2 Diabetes Clinical Endocrinology, March 15, 2013

11 Effects of pioglitazone versus glimepiride exposure on hepatocellular fat content in type 2 diabetes Diabetes, Obesity and Metabolism, April 10, 2013

12 Telmisartan as a metabolic sartan: The first meta-analysis of randomized controlled trials in metabolic syndrome Journal of the American Society of Hypertension, April 24, 2013

13 Validation of a Novel Method for Determining the Renal Threshold for Glucose Excretion in Untreated and Canagliflozin-treated Subjects With Type 2 Diabetes Mellitus Journal of Clinical Endocrinology and Metabolism, April 15, 2013

14 Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: A randomized clinical trial Clinical Nutrition, March 26, 2013

15 Desiccated Thyroid Extract Compared With Levothyroxine in the Treatment of Hypothyroidism: A Randomized, Double-Blind, Crossover Study Journal of Clinical Endocrinology and Metabolism, March 29, 2013

16 Effect of insulin degludec versus sitagliptin in patients with type 2 diabetes uncontrolled on oral antidiabetic agents Diabetes, Obesity and Metabolism, April 12, 2013

17 Higher doses of cabergoline further improve metabolic parameters in patients with prolactinoma regardless of the degree of reduction in prolactin levels Clinical Endocrinology, March 29, 2013

18 Metformin Inhibits Goitrogenous Effects of Type 2 Diabetes European Journal of Endocrinology, April 11, 2013

19 Over-the-Counter-Drug-Induced Thyroid Disorders Endocrine Practice, March 26, 2013 Free full text

20 Drug Prescription Patterns in Patients With Addison's Disease: A Swedish Population-Based Cohort Study Journal of Clinical Endocrinology and Metabolism, April 2, 2013

Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetes more

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Endocrinology - Pharmacology/kinetics News & Articles

Articles

Clinical Pearls in Endocrinology

Highlights in Endocrinology

Regulatory protein identified in T1DM

Statins increase risk of DM in postmenopausal women

Determining the basal insulin dosage in T2DM

Most Popular Endocrinology Articles

Other Topics in Endocrinology