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Endocrinology - Pharmacology/kinetics News & Articles

MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.

Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.

Your Unread Messages in Endocrinology

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Articles

Latest (2) Full Text Articles (199) Focus on Parathyroid/Adrenal
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

941 Cinacalcet Improves Bone Density in Post–Kidney Transplant Hyperparathyroidism Transplantation Proceedings, December 2, 2010

942 Use of sulphonylurea and cancer in type 2 diabetes - The Hong Kong Diabetes Registry Diabetes Research and Clinical Practice, November 30, 2010

943 Metformin Use and Mortality Among Patients With Diabetes and Atherothrombosis Full Text JAMA Internal Medicine, November 29, 2010    Clinical Article

944 Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis Cancer Prevention Research, November 29, 2010    Evidence Based Medicine

945 Treatment of Obesity With Combination Pharmacotherapy American Journal of Therapeutics, November 29, 2010

946 Role of the addition of cabergoline to the management of acromegalic patients resistant to longterm treatment with octreotide LAR Pituitary, November 29, 2010

947 Multiple doses of pegylated long-acting growth hormone are well tolerated in healthy male volunteers and possess a potential once-weekly treatment profile Clinical Endocrinology, November 23, 2010

948 Hydrochloride pioglitazone decreases urinary cytokines excretion in type 2 diabetes Clinical Endocrinology, November 22, 2010

949 Saxagliptin: A New Dipeptidyl Peptidase-4 Inhibitor for Type 2 Diabetes Cardiology in Review, November 19, 2010    Clinical Article

950 Efficacy and Acceptability of Lanreotide Autogel 120 mg at Different Dose Intervals in Patients with Acromegaly Previously Treated with Octreotide LAR Experimental and Clinical Endocrinology & Diabetes, November 18, 2010    Clinical Article

951 Leptin replacement improves postprandial glycemia and insulin sensitivity in human immunodeficiency virus-infected lipoatrophic men treated with pioglitazone: a pilot study Metabolism, November 18, 2010

952 2-Methoxyestradiol: New perspectives in colon carcinoma treatment Molecular and Cellular Endocrinology, November 17, 2010    Clinical Article

953 Efficacy and Harms of the Hypoglycemic Agent Pramlintide in Diabetes Mellitus Full Text Annals of Family Medicine, November 16, 2010

954 Glucose regulation influences treatment outcome in ranibizumab treatment for diabetic macular edema Journal of Diabetes and its Complications, November 16, 2010    Clinical Article

955 Colesevelam HCl Powder for Oral Suspension versus Cholestyramine Powder for Oral Suspension: Comparison of Acceptability and Tolerability Endocrine Practice, November 15, 2010

956 The combination of bortezomib and resveratrol may prevent muscle wasting in diabetes Medical Hypotheses, November 11, 2010    Clinical Article

957 Evaluation of Efficacy and Tolerability of Gliclazide and Metformin Combination: A Multicentric Study in Patients With Type 2 Diabetes Mellitus Uncontrolled on Monotherapy With Sulfonylurea or Metformin American Journal of Therapeutics, November 11, 2010    Clinical Article

958 Modulation of Advanced Glycation End Products by Candesartan in Patients with Diabetic Kidney Disease-A Dose-Response Relationship Study American Journal of Therapeutics, November 11, 2010    Clinical Article

959 Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial The Lancet - Early Online Publication, November 10, 2010    Clinical Article

960 Phase II Study of Daily Sunitinib in FDG-PET–Positive, Iodine-Refractory Differentiated Thyroid Cancer and Metastatic Medullary Carcinoma of the Thyroid with Functional Imaging Correlation Full Text Clinical Cancer Research, November 10, 2010    Clinical Article

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Clinical Pearls in Endocrinology

Highlights in Endocrinology

Regulatory protein identified in T1DM

As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.

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Statins increase risk of DM in postmenopausal women

As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up

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Determining the basal insulin dosage in T2DM

Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.

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Most Popular Endocrinology Articles

Last month's top read Top Articles of 2012

1 Mortality outcomes of different sulfonylurea drugs. The results of a 14-year cohort study of type 2 diabetic patients European Journal of Endocrinology, May 13, 2013

2 Dexamethasone for the Prevention of Recurrent Laryngeal Nerve Palsy and Other Complications After Thyroid Surgery JAMA Otolaryngology—Head & Neck Surgery, May 17, 2013

3 Randomized Trial of Continuous Subcutaneous Delivery of Exenatide by ITCA 650 Versus Twice-Daily Exenatide Injections in Metformin-Treated Type 2 Diabetes Diabetes Care, May 6, 2013

4 Effects of co-administration of candesartan with pioglitazone on inflammatory parameters in hypertensive patients with type 2 diabetes mellitus: a preliminary report Cardiovascular Diabetology, May 15, 2013    Free full text

5 Rivoglitazone: A New Thiazolidinedione for the Treatment of Type 2 Diabetes Mellitus Annals of Pharmacotherapy, May 2, 2013

6 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, April 9, 2013

7 Subantimicrobial-dose doxycycline treatment increases serum cholesterol efflux capacity from macrophages Inflammation Research, May 9, 2013

8 Effects of patient-tailored atorvastatin therapy on ameliorating the levels of atherogenic lipids and inflammation beyond lowering low-density lipoprotein cholesterol in patients with type 2 diabetes Journal of Diabetes Investigation, April 3, 2013    Review Article

9 Dapagliflozin a Glucose-Regulating Drug With Diuretic Properties in Subjects With Type 2 Diabetes Diabetes, Obesity and Metabolism, May 14, 2013

10 Effect of thiazolidinediones and insulin on cognitive outcomes in ACCORD-MIND Journal of Diabetes and its Complications, May 16, 2013

11 Gender and racial disparities in adherence to statin therapy: A meta-analysis American Heart Journal, April 30, 2013    Evidence Based Medicine    Review Article

12 Determinants of Maternal Triglycerides in Women With Gestational Diabetes Mellitus in the Metformin in Gestational Diabetes (MiG) Study Diabetes Care, March 8, 2013

13 Concomitant use of miglitol and mitiglinide as initial combination therapy in type 2 diabetes mellitus Diabetes Research and Clinical Practice, May 29, 2013

14 Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial The Lancet, May 16, 2013

15 Effect of sulfonylurea dose escalation on hemoglobin A1c in Veterans Affairs patients with type 2 diabetes Acta Diabetologia, April 26, 2013    Review Article

16 A Randomized, Placebo-Controlled Trial of Selenium Supplementation in Patients With Type 2 Diabetes: Effects on Glucose Homeostasis, Oxidative Stress, and Lipid Profile American Journal of Therapeutics, May 8, 2013

17 Clinical Outcome Following Stringent Discontinuation of Dual Anti-Platelet Therapy After 12 Months in Real-World Patients Treated With Second-Generation Zotarolimus-Eluting Resolute and Everolimus-Eluting Xience V Stents: Two-Year Follow-up of the Randomized TWENTE Trial JACC - Journal of the American College of Cardiology, April 26, 2013

18 Treatment with metformin is associated with higher remission rate in diabetic patients with thyroid cancer Journal of Clinical Endocrinology and Metabolism, May 28, 2013

19 The role of co-morbidity in the selection of antidiabetic pharmacotherapy in type-2 diabetes Cardiovascular Diabetology, April 12, 2013    Free full text

20 Vildagliptin in addition to metformin improves retinal blood flow and erythrocyte deformability in patients with type 2 diabetes mellitus -- results from an exploratory study Cardiovascular Diabetology, April 12, 2013    Free full text

Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetesmore

Other Topics in Endocrinology

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