Endocrinology - Pharmacology/kinetics News & Articles

MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.

Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.

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Articles

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

41 Masked Hypertension in Diabetes Mellitus-Treatment Implications for Clinical Practice Hypertension, April 19, 2013 Clinical Article

42 The Role of Plasma Renin Activity, Age, and Race in Selecting Effective Initial Drug Therapy for Hypertension American Journal of Hypertension, April 19, 2013 Clinical Article

43 Trends in selection and timing of first-line pharmacotherapy in older patients with Type 2 diabetes diagnosed between 1994 and 2006 Diabetic Medicine, April 18, 2013 Clinical Article

44 The association between adherence to oral anti-diabetic drugs and hypoglycaemia in persons with Type 2 diabetes Diabetic Medicine, April 18, 2013 Clinical Article

45 In-treatment HDL cholesterol levels and development of new diabetes mellitus in hypertensive patients: The LIFE Study Diabetic Medicine, April 18, 2013 Clinical Article

46 A Review of BMI-Mortality Paradox and Fitness in African American and Caucasian Men with Type 2 Diabetes Full Text Clinical Diabetes, April 18, 2013 Review Article

47 Update on the Antimicrobial Management of Foot Infections in Patients With Diabetes Full Text Clinical Diabetes, April 18, 2013 Review Article

48 Pesticides and human diabetes: a link worth exploring? Diabetic Medicine, April 18, 2013 Review Article

49 Cardiovascular Safety Of Sulfonylureas: A Meta-Analysis Of Randomised Clinical Trials Diabetes, Obesity and Metabolism, April 18, 2013 Evidence Based Medicine Clinical Article

50 Mechanisms of Glucose Lowering of Dipeptidyl Peptidase-4 Inhibitor Sitagliptin When Used Alone or With Metformin in Type 2 Diabetes: A double-tracer study Diabetes Care, April 17, 2013 Clinical Article

51 The Use of Aromatase Inhibitors for Ovulation Induction and Superovulation Journal of Clinical Endocrinology and Metabolism, April 17, 2013 Review Article

52 Tolerability and efficacy of glycemic control with saxagliptin in older patients (aged ≥ 65 years) with inadequately controlled type 2 diabetes mellitus Full Text Clinical Interventions in Aging, April 16, 2013 Clinical Article

53 Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics Full Text Drug Design, Development and Therapy, April 16, 2013 Clinical Article

54 Cost-effectiveness of insulin detemir compared with NPH insulin in people with type 2 diabetes in Denmark, Finland, Norway, and Sweden Journal of Medical Economics , April 16, 2013 Review Article

55 Validation of a Novel Method for Determining the Renal Threshold for Glucose Excretion in Untreated and Canagliflozin-treated Subjects With Type 2 Diabetes Mellitus Journal of Clinical Endocrinology and Metabolism, April 15, 2013 Clinical Article

56 Antihypertensive treatment in diabetic patients- Review of current data Maturitas, April 15, 2013 Review Article

57 Discordant effects of rosiglitazone on novel inflammatory biomarkers American Heart Journal, April 15, 2013 Clinical Article

58 Effect of insulin degludec versus sitagliptin in patients with type 2 diabetes uncontrolled on oral antidiabetic agents Diabetes, Obesity and Metabolism, April 12, 2013 Clinical Article

59 The role of co-morbidity in the selection of antidiabetic pharmacotherapy in type-2 diabetes Full Text Cardiovascular Diabetology, April 12, 2013 Clinical Article

60 Vildagliptin in addition to metformin improves retinal blood flow and erythrocyte deformability in patients with type 2 diabetes mellitus -- results from an exploratory study Full Text Cardiovascular Diabetology, April 12, 2013 Clinical Article

50 available pages First Previous 3 4 5 6 7 8 9 10 11 12 Next Last

Clinical Pearls in Endocrinology

Pioglitazone can reduce the risk of conversion of impaired glucose tolerance to type 2 diabetes mellitus by 72%, but it was also associated with significant weight gain and edema
The most commonly reported adverse event associated with Janumet in the treatment of type 2 diabetes is diarrhea, followed by upper respiratory tract infection and headache
Maturity-onset diabetes of the young (MODY)3 can be treated with sulfonylureas with excellent results for decades

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Highlights in Endocrinology

Regulatory protein identified in T1DM

As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.

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Statins increase risk of DM in postmenopausal women

As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up

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Determining the basal insulin dosage in T2DM

Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.

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Most Popular Endocrinology Articles

Last month's top read Top Articles of 2012

1 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, April 9, 2013

2 Trends in selection and timing of first-line pharmacotherapy in older patients with Type 2 diabetes diagnosed between 1994 and 2006 Diabetic Medicine, April 18, 2013

3 Effects of patient-tailored atorvastatin therapy on ameliorating the levels of atherogenic lipids and inflammation beyond lowering low-density lipoprotein cholesterol in patients with type 2 diabetes Journal of Diabetes Investigation, April 3, 2013 Review Article

4 Hormonal versus non-hormonal contraceptives in women with diabetes mellitus type 1 and 2 Cochrane Reviews, April 1, 2013 Review Article

5 Who Needs an Artificial Pancreas? Journal of Diabetes, April 25, 2013

6 Safety and Effect of Very Low Levels of Low-Density Lipoprotein Cholesterol on Cardiovascular Events The American Journal of Cardiology, April 4, 2013

7 Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics Drug Design, Development and Therapy, April 16, 2013 Free full text

8 Determinants of Maternal Triglycerides in Women With Gestational Diabetes Mellitus in the Metformin in Gestational Diabetes (MiG) Study Diabetes Care, March 8, 2013

9 Effect of sulfonylurea dose escalation on hemoglobin A1c in Veterans Affairs patients with type 2 diabetes Acta Diabetologia, April 26, 2013 Review Article

10 The Effect of Chronic Twice Daily Exenatide Treatment on β-cell Function in New Onset Type 2 Diabetes Clinical Endocrinology, March 15, 2013

11 Effects of pioglitazone versus glimepiride exposure on hepatocellular fat content in type 2 diabetes Diabetes, Obesity and Metabolism, April 10, 2013

12 Telmisartan as a metabolic sartan: The first meta-analysis of randomized controlled trials in metabolic syndrome Journal of the American Society of Hypertension, April 24, 2013

13 Validation of a Novel Method for Determining the Renal Threshold for Glucose Excretion in Untreated and Canagliflozin-treated Subjects With Type 2 Diabetes Mellitus Journal of Clinical Endocrinology and Metabolism, April 15, 2013

14 Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: A randomized clinical trial Clinical Nutrition, March 26, 2013

15 Desiccated Thyroid Extract Compared With Levothyroxine in the Treatment of Hypothyroidism: A Randomized, Double-Blind, Crossover Study Journal of Clinical Endocrinology and Metabolism, March 29, 2013

16 Effect of insulin degludec versus sitagliptin in patients with type 2 diabetes uncontrolled on oral antidiabetic agents Diabetes, Obesity and Metabolism, April 12, 2013

17 Higher doses of cabergoline further improve metabolic parameters in patients with prolactinoma regardless of the degree of reduction in prolactin levels Clinical Endocrinology, March 29, 2013

18 Metformin Inhibits Goitrogenous Effects of Type 2 Diabetes European Journal of Endocrinology, April 11, 2013

19 Over-the-Counter-Drug-Induced Thyroid Disorders Endocrine Practice, March 26, 2013 Free full text

20 Drug Prescription Patterns in Patients With Addison's Disease: A Swedish Population-Based Cohort Study Journal of Clinical Endocrinology and Metabolism, April 2, 2013

Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetes more

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Endocrinology - Pharmacology/kinetics News & Articles

Articles

Clinical Pearls in Endocrinology

Highlights in Endocrinology

Regulatory protein identified in T1DM

Statins increase risk of DM in postmenopausal women

Determining the basal insulin dosage in T2DM

Most Popular Endocrinology Articles

Other Topics in Endocrinology