Endocrinology - Atherosclerosis/Lipids News & Articles

MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.

Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (7) Full Text Articles (262) Focus on Pediatrics

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

1 LDL-cholesterol versus non-HDL-to-HDL-cholesterol ratio and risk for coronary heart disease in type 2 diabetes European Journal of Preventive Cardiology, June 19, 2013 Clinical Article

2 Lipoprotein abnormalities in patients with type 2 diabetes and metabolic syndrome Full Text JAAPA, June 19, 2013 Clinical Article

3 Cardiovascular disease: Is LDL-C level a good indicator of coronary risk in people with nondialysis-dependent CKD Nature Reviews Nephrology, June 19, 2013

4 Do patients on statins also need niacin Full Text JAAPA, June 19, 2013 Clinical Article

5 Risk factors for subclinical atherosclerosis in HIV-infected patients under and over 40 years: a case--control study Full Text BMC Infectious Diseases, June 19, 2013 Clinical Article

6 Direct-to-consumer television advertising exposure, diagnosis with high cholesterol, and statin use Journal of General Internal Medicine, June 19, 2013 Evidence Based Medicine Clinical Article

7 Multimodality imaging of carotid atherosclerotic plaque: Going beyond stenosis Full Text Indian Journal of Radiology and Imaging, June 19, 2013

Prior Articles

8 Analysis and modelling of cholesterol and high-density lipoprotein cholesterol changes across the range of C-reactive protein levels in clinical practice as an aid to better understanding of inflammation-lipid interactions Annals of Rheumatic Diseases, June 18, 2013 Clinical Article

9 CKD and cardiovascular disease in the atherosclerosis risk in communities (ARIC) study: Interactions with age, sex, and race American Journal of Kidney Diseases, June 18, 2013 Clinical Article

10 Serum proprotein convertase subtilisin/kexin type 9 and cell surface low-density lipoprotein receptor Circulation, June 18, 2013 Clinical Article

11 Hyperlipidemia attenuates vascular endothelial growth factor–induced angiogenesis, impairs cerebral blood flow, and disturbs stroke recovery via decreased pericyte coverage of brain endothelial cells Arteriosclerosis, Thrombosis, and Vascular Biology, June 18, 2013 Clinical Article

12 Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks Arteriosclerosis, Thrombosis, and Vascular Biology, June 18, 2013 Clinical Article

13 Impaired lipoprotein processing in HIV patients on antiretroviral therapy Arteriosclerosis, Thrombosis, and Vascular Biology, June 18, 2013 Clinical Article

14 Mechanisms of coronary thrombosis in cigarette smoke exposure Arteriosclerosis, Thrombosis, and Vascular Biology, June 18, 2013 Clinical Article

15 Lipid profiles for HER2-positive breast cancer Anticancer Research, June 18, 2013 Clinical Article

16 Socioeconomic status and dyslipidemia in Korean adults: The 2008-2010 Korea National Health and Nutrition Examination Survey Preventive Medicine, June 18, 2013 Clinical Article

17 Activation of the mitochondrial ATP-sensitive K+ channel reduces apoptosis of spleen mononuclear cells induced by hyperlipidemia Full Text Lipids in Health and Disease, June 17, 2013

18 Targeting of Acyl-CoA synthetase 5 decreases jejunal fatty acid activation with no effect on dietary long-chain fatty acid absorption Full Text Lipids in Health and Disease, June 17, 2013

19 Involvement of advanced glycation end product–induced asymmetric dimethylarginine generation in endothelial dysfunction Diabetes & Vascular Disease Research, June 17, 2013 Review Article

20 Maternal lipids are as important as glucose for fetal growth: findings from the Pune Maternal Nutrition Study Diabetes Care, June 14, 2013 Review Article

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Clinical Pearls in Endocrinology

Pioglitazone can reduce the risk of conversion of impaired glucose tolerance to type 2 diabetes mellitus by 72%, but it was also associated with significant weight gain and edema
The most commonly reported adverse event associated with Janumet in the treatment of type 2 diabetes is diarrhea, followed by upper respiratory tract infection and headache
Maturity-onset diabetes of the young (MODY)3 can be treated with sulfonylureas with excellent results for decades

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Highlights in Endocrinology

Regulatory protein identified in T1DM

As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.

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Statins increase risk of DM in postmenopausal women

As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up

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Determining the basal insulin dosage in T2DM

Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.

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Most Popular Endocrinology Articles

Last month's top read Top Articles of 2012

1 LDL cholesterol in CKD-to treat or not to treat? Kidney International, May 23, 2013

2 Statins and lipid metabolism Current Opinion in Lipidology, May 24, 2013 Review Article

3 Associations of TSH within the reference range with future blood pressure and lipid concentrations. 11-year follow-up of the HUNT Study European Journal of Endocrinology, May 6, 2013

4 Meta-Analysis of Impact of Different Types and Doses of Statins on New-Onset Diabetes Mellitus The American Journal of Cardiology, April 4, 2013 Evidence Based Medicine Review Article

5 Blood Cholesterol Trends 2001-2011 in the United States: Analysis of 105 Million Patient Records PLOS ONE, May 17, 2013 Review Article

6 The Effect of Intensive Glucose Lowering on Lipoprotein Particle Profiles and Inflammatory Markers in the Veterans Affairs Diabetes Trial (VADT) Diabetes Care, April 1, 2013

7 Evaluation of the effect of omega-3 fatty acids in the treatment of premenstrual syndrome: A pilot trial Complementary Therapies in Medicine, May 9, 2013

8 Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy European Heart Journal, May 16, 2013

9 The metabolic inter-relationships between changes in waist circumference, triglycerides, insulin sensitivity and small, dense low-density lipoprotein particles with acute weight loss in clinically obese children and adolescents Pediatric Obesity, April 26, 2013 Review Article

10 Phytosterol capsules and serum cholesterol in hypercholesterolemia: A randomized controlled trial Atherosclerosis, May 13, 2013

11 Achievement of LDL-C goals depends on baseline LDL-C and choice and dose of statin: An analysis from the VOYAGER database European Journal of Preventive Cardiology, May 10, 2013

12 Effect of a high-fat challenge on the proteome of human postprandial plasma Clinical Nutrition, May 8, 2013

13 The association of elective hormone therapy with changes in lipids among glucose intolerant postmenopausal women in the diabetes prevention program Metabolism, May 9, 2013

14 The effect of HIV infection on atherosclerosis and lipoprotein metabolism: A one year prospective study Atherosclerosis, May 13, 2013

15 Elevated PCSK9 Levels in Untreated Patients With Heterozygous or Homozygous Familial Hypercholesterolemia and the Response to High-Dose Statin Therapy Journal of the American Heart Association, May 8, 2013 Free full text

16 The risk of venous thromboembolism in patients with rheumatoid arthritis Arthritis Care & Research , May 13, 2013

17 Lack of protective role of HDL-C in patients with coronary artery disease undergoing elective coronary artery bypass grafting European Heart Journal, May 29, 2013

18 Antioxidized LDL Antibodies Are Associated With Different Metabolic Pathways in Patients With Atherosclerotic Plaque and Type 2 Diabetes Diabetes Care, December 4, 2012

19 Parathyroid hormone and cardiovascular disease events: A systematic review and meta-analysis of prospective studies American Heart Journal, April 30, 2013 Evidence Based Medicine Review Article

20 Trends in Predicted 10-Year Risk of Coronary Heart Disease and Cardiovascular Disease among US Adults from 1999 to 2010 JACC - Journal of the American College of Cardiology, April 12, 2013

Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetes more

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Endocrinology - Atherosclerosis/Lipids News & Articles

Articles

Prior Articles

Clinical Pearls in Endocrinology

Highlights in Endocrinology

Regulatory protein identified in T1DM

Statins increase risk of DM in postmenopausal women

Determining the basal insulin dosage in T2DM

Most Popular Endocrinology Articles

Other Topics in Endocrinology