Endocrinology - Endocrine Oncology News & Articles

MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.

Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

21 Cytomorphological Factors and BRAF Mutation Predicting Risk of Lymph Node Metastasis in Preoperative Liquid-Based Fine Needle Aspirations of Papillary Thyroid Carcinoma Acta Cytologica, May 7, 2013 Clinical Article

22 Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors Oncogene, May 7, 2013 Review Article

23 Aberrant anaplastic lymphoma kinase expression in high-grade pulmonary neuroendocrine carcinoma Journal of Clinical Pathology, May 7, 2013 Clinical Article

24 Vitamin D3 levels and insulin resistance in papillary thyroid cancer patients Medical Oncology, May 6, 2013 Clinical Article

25 BRAF and RAS Mutations in Follicular Variants of Papillary Thyroid Carcinoma Endocrine Pathology, May 6, 2013 Review Article

26 Patients Experiences Following Local-Regional Recurrence of Thyroid Cancer: A Qualitative Study Journal of Surgical Oncology, May 6, 2013 Clinical Article

27 Efatutazone, an Oral PPAR-{gamma} Agonist, in Combination with Paclitaxel in Anaplastic Thyroid Cancer: Results of a Multicenter Phase 1 Trial Journal of Clinical Endocrinology and Metabolism, May 6, 2013 Review Article

28 Thyroglobulin levels and thyroglobulin doubling time independently predict a positive 18F-FDG PET/CT scan in patients with biochemical recurrence of differentiated thyroid carcinoma European Journal of Nuclear Medicine & Molecular Imaging, May 6, 2013 Clinical Article

29 Complete Genomic Landscape of a Recurring Sporadic Parathyroid Carcinoma The Journal of Pathology, May 6, 2013 Clinical Article

30 Identification of a novel androgen receptor mutation in a family with multiple components compatible with the testicular dysgenesis syndrome Journal of Clinical Endocrinology and Metabolism, May 6, 2013 Review Article

31 Adrenocortical carcinoma: A population-based study on incidence and survival in the Netherlands since 1993 European Journal of Cancer, May 6, 2013 Review Article Clinical Article

32 Missense Polymorphisms in XIAP-Associated Factor-1 (XAF1) and Risk of Papillary Thyroid Cancer: Correlation with Clinicopathological Features Anticancer Research, May 6, 2013 Clinical Article

33 Should an Involved but Functioning Recurrent Laryngeal Nerve be Shaved or Resected in a Locally Advanced Papillary Thyroid Carcinoma? Annals of Surgical Oncology, May 6, 2013 Review Article

34 Surgery for adrenocortical carcinoma in the Netherlands: analysis of national cancer registry data European Journal of Endocrinology, May 6, 2013 Clinical Article

35 Could 18F-FDG-PET/CT avoid unnecessary thyroidectomies in patients with cytological diagnosis of follicular neoplasm Langenbeck's Archives of Surgery, May 3, 2013 Clinical Article

36 Recent advances in adrenocortical carcinoma in adults Current Opinion in Endocrinology, Diabetes and Obesity, May 2, 2013 Review Article

37 Genetics of pheochromocytoma and paraganglioma syndromes: new advances and future treatment options Current Opinion in Endocrinology, Diabetes and Obesity, May 2, 2013 Review Article

38 Fasting proinsulin levels are significantly associated with 20 year cancer mortality rates Diabetologia - Clinical and Experimental Diabetes and Metabolism, May 1, 2013 Review Article

39 Calcitonin measurement in aspiration needle washout fluids has higher sensitivity than cytology in detecting medullary thyroid cancer: a retrospective multicenter study Clinical Endocrinology, May 1, 2013 Clinical Article

40 Peptide receptor radionuclide therapy (PRRT) for GEP-NETs Best Practice & Research Clinical Gastroenterology , May 1, 2013 Review Article

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Clinical Pearls in Endocrinology

Pioglitazone can reduce the risk of conversion of impaired glucose tolerance to type 2 diabetes mellitus by 72%, but it was also associated with significant weight gain and edema
The most commonly reported adverse event associated with Janumet in the treatment of type 2 diabetes is diarrhea, followed by upper respiratory tract infection and headache
Maturity-onset diabetes of the young (MODY)3 can be treated with sulfonylureas with excellent results for decades

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Highlights in Endocrinology

Regulatory protein identified in T1DM

As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.

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Statins increase risk of DM in postmenopausal women

As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up

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Determining the basal insulin dosage in T2DM

Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.

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Most Popular Endocrinology Articles

Last month's top read Top Articles of 2012

1 Differentiated thyroid carcinoma: defining new paradigms for the post-operative management Endocrine-Related Cancer, April 11, 2013 Review Article

2 Parathyroid Carcinosarcoma: A Rare Parathyroid Carcinoma With Normal Parathyroid Hormone Levels International Journal of Surgical Pathology, April 4, 2013

3 Progress in molecular-based management of differentiated thyroid cancer The Lancet, April 17, 2013

4 Radioactive Iodine in the treatment of Medullary Thyroid Carcinoma: a controlled multicenter study European Journal of Endocrinology, March 7, 2013

5 Selective use of RAI for ablation and adjuvant therapy after total thyroidectomy for differentiated thyroid cancer: A practical approach to clinical decision making Oral Oncology , April 24, 2013

6 Clinical analysis of prophylactic central neck dissection for papillary thyroid carcinoma Clinical and Translational Oncology, April 22, 2013

7 Association between braf v600e mutation and mortality in patients with papillary thyroid cancer JAMA, April 26, 2013

8 Endosonographic and cyst fluid characteristics of cystic pancreatic neuroendocrine tumours: A multicentre case series Digestive and Liver Diseases, April 15, 2013

9 Benefit-Risk Balance of Reoperation for Persistent Medullary Thyroid Cancer Annals of Surgery, April 15, 2013

10 Post-surgical thyroid ablation with low or high radioiodine activities results in similar outcomes in intermediate risk differentiated thyroid cancer patients European Journal of Endocrinology, April 19, 2013 Review Article

11 Comparison of 99mTc-HYNIC-TOC and HYNIC-TATE Octreotide Scintigraphy With FDG PET and 99mTc-MIBI in Local Recurrent or Distant Metastatic Thyroid Cancers Clinical Nuclear Medicine , April 16, 2013 Review Article

12 Protective effect of intraoperative nerve monitoring against recurrent laryngeal nerve injury during re-exploration of the thyroid World Journal of Surgical Oncology, April 25, 2013 Free full text Review Article

13 Evolving Approaches to Patients with Advanced Differentiated Thyroid Cancer Endocrine Reviews, April 11, 2013 Review Article

14 Central lymph node dissection in patients with papillary thyroid cancer: a population level analysis of 14,257 cases The American Journal of Surgery, March 6, 2013 Review Article

15 Urapidil in the Preoperative Treatment of Pheochromocytomas: A Safe and Cost-effective Method World Journal of Surgery, April 10, 2013

16 Lessons learned and questions unanswered from use of multitargeted kinase inhibitors in medullary thyroid cancer Oral Oncology , April 15, 2013 Review Article

17 DNA Microarray and miRNA Analyses Reinforce the Classification of Follicular Thyroid Tumors Journal of Clinical Endocrinology and Metabolism, April 9, 2013 Review Article

18 Variation in the Management of Thyroid Cancer Journal of Clinical Endocrinology and Metabolism, March 29, 2013 Review Article

19 Brain metastases from papillary thyroid carcinomas Virchows Archiv, April 5, 2013

20 The endocrinology of exercise Internal and Emergency Medicine, March 27, 2013 Review Article
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Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetes more

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Endocrinology - Endocrine Oncology News & Articles

Articles

Clinical Pearls in Endocrinology

Highlights in Endocrinology

Regulatory protein identified in T1DM

Statins increase risk of DM in postmenopausal women

Determining the basal insulin dosage in T2DM

Most Popular Endocrinology Articles

Other Topics in Endocrinology