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Endocrinology - Bone Metabolism News & Articles
MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
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Articles
Latest (2) Full Text Articles (100) Focus on Bone Metabolism821 Dynamic contrast-enhanced MRI for monitoring bisphosphonate therapy in Pagets disease of bone Skeletal Radiology, May 22, 2012
822 Assessment of lumbar vertebrae morphology by magnetic resonance imaging in osteoporosis Skeletal Radiology, May 22, 2012
823 Corticosteroid use and bone mineral accretion in children with asthma: Effect modification by vitamin D The Journal of Allergy and Clinical Immunology, May 21, 2012 Clinical Article
824 Osteoporotic profiles in elderly patients with symptomatic lumbar spinal canal stenosis Full Text Indian Journal of Orthopaedics, May 21, 2012
825 Multifactorial analysis of risk factors for reduced bone mineral density among postmenopausal women Archives of Medical Science, May 18, 2012
826 Osteocyte Apoptosis and Lipid Infiltration as Mechanisms of Alcohol-Induced Bone Loss Alcohol and Alcoholism , May 18, 2012
827 Significant inverse relationship between serum undercarboxylated osteocalcin and glycemic control in maintenance hemodialysis patients Osteoporosis International, May 17, 2012
828 Does frequency of resistance training affect tibial cortical bone density in older women? A randomized controlled trial Osteoporosis International, May 17, 2012
829 Mitochondrial DNA Copy Number in Peripheral Blood Is Associated with Femoral Neck Bone Mineral Density in Postmenopausal Women The Journal of Rheumatology, May 17, 2012
830 Are long-term bisphosphonate users a reality? Dose years for current bisphosphonate users assessed using the danish national prescription database Osteoporosis International, May 17, 2012
831 Phosphate homeostasis and its role in bone health Pediatric Nephrology, May 16, 2012
832 High Circulating Sclerostin is Present in Patients with Thalassemia-associated Osteoporosis and Correlates with Bone Mineral Density Hormone and Metabolic Research, May 16, 2012
833 Determinants of bone mineral density in stable kidney transplant recipients Journal of Nephrology, May 16, 2012
834 Impaired bone mineralization accompanied by low vitamin D and secondary hyperparathyroidism in patients with femoral neck fracture Osteoporosis International, May 15, 2012
835 The association of bone mineral density and parathyroid hormone with serum magnesium in adult patients with sickle-cell anaemia Archives of Medical Science, May 15, 2012
836 Hip fracture patients in India have vitamin D deficiency and secondary hyperparathyroidism Osteoporosis International, May 15, 2012
837 Estimating the excess costs for patients with incident fractures, prevalent fractures, and nonfracture osteoporosis Osteoporosis International, May 14, 2012
838 C-Type natriuretic peptide forms in adult hyperthyroidism: correlation with thyroid hormones and markers of bone turnover Clinical Endocrinology, May 11, 2012
839 Serum sclerostin levels were positively correlated with fat mass and bone mineral density in Central South Chinese postmenopausal women Clinical Endocrinology, May 11, 2012
840 Neridronate improves bone mineral density and reduces back pain in β-thalassaemia patients with osteoporosis: results from a phase 2, randomized, parallel-arm, open-label study British Journal of Haematology, May 11, 2012 Clinical Article
Clinical Pearls in Endocrinology
- Pioglitazone can reduce the risk of conversion of impaired glucose tolerance to type 2 diabetes mellitus by 72%, but it was also associated with significant weight gain and edema
- The most commonly reported adverse event associated with Janumet in the treatment of type 2 diabetes is diarrhea, followed by upper respiratory tract infection and headache
- Maturity-onset diabetes of the young (MODY)3 can be treated with sulfonylureas with excellent results for decades
Highlights in Endocrinology
Regulatory protein identified in T1DM
As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.
Read the article summaryStatins increase risk of DM in postmenopausal women
As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up
Read the article summaryDetermining the basal insulin dosage in T2DM
Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.
Read the article summaryMost Popular Endocrinology Articles
Last month's top read Top Articles of 20121 PTH replacement therapy of hypoparathyroidism Osteoporosis International, April 17, 2013 Review Article
2 Osteoporosis treatment European Journal of Internal Medicine , April 24, 2013
3 Effect of Pioglitazone on Body Composition and Bone Density in Subjects with Prediabetes in the ACT NOW Trial Diabetes, Obesity and Metabolism, April 3, 2013 Review Article
4 Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels -- Results from a randomized trial European Journal of Internal Medicine , April 11, 2013
5 Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults Journal of Clinical Endocrinology and Metabolism, April 4, 2013
6 Guidelines for the use of bone metabolic markers in the diagnosis and treatment of osteoporosis (2012 edition) Journal of Bone and Mineral Metabolism, February 5, 2013 Clinical Guideline
7 Hip bone loss is attenuated with 1000 IU but not 400 IU daily vitamin D3: a 1 year double-blind RCT in postmenopausal women Journal of Bone and Mineral Research, April 15, 2013
8 Bisphosphonates and risk of subtrochanteric, femoral shaft, and atypical femur fracture: A systematic review and meta-analysis Journal of Bone and Mineral Research, February 14, 2013 Evidence Based Medicine
9 Relationships Between Serum Adiponectin and Bone Density, Adiposity and Calcified Atherosclerotic Plaque in the African American-Diabetes Heart Study Journal of Clinical Endocrinology and Metabolism, April 2, 2013 Review Article
10 Regional migratory osteoporosis and transient osteoporosis of the hip: are they all the same Clinical Rheumatology, April 9, 2013 Review Article
11 Parathyroid hormone changes following denosumab treatment in postmenopausal osteoporosis Clinical Endocrinology, March 6, 2013
12 The effects of diabetes mellitus and diabetic nephropathy on bone and mineral metabolism in T2DM patients Diabetes Research and Clinical Practice, April 5, 2013 Review Article
13 The omega-6 arachidonic fatty acid, but not the omega-3 fatty acids, inhibits osteoblastogenesis and induces adipogenesis of human mesenchymal stem cells: potential implication in osteoporosis Osteoporosis International, April 22, 2013 Review Article
14 Where Are We 10 Years After the Womens Health Initiative? Journal of Clinical Endocrinology and Metabolism, April 19, 2013
15 Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures Journal of Bone and Mineral Research, April 5, 2013
16 Bone mineral density testing: Is a T score enough to determine the screening interval? Cleveland Clinic Journal of Medicine, April 3, 2013 Free full text
17 Continuous long-term anti-TNF therapy does not lead to an increase in the rate of new bone formation over 8 years in patients with ankylosing spondylitis Annals of Rheumatic Diseases, April 9, 2013
18 Effects of total bilirubin on the prevalence of osteoporosis in postmenopausal women without potential liver disease Journal of Bone and Mineral Metabolism, April 12, 2013 Review Article
19 Vitamin D and the cardiovascular system Osteoporosis International, March 14, 2013
20 Eldecalcitol: newly developed active vitamin D3 analog for the treatment of osteoporosis Expert Opinion on Pharmacotherapy, April 8, 2013
Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetes more
Other Topics in Endocrinology
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