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Endocrinology - Basic Science/Genetics News & Articles
MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
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Articles
Latest (6) Full Text Articles (521) Focus on Reproduction981 The influence of body-mass index and renin-angiotensin-aldosterone system activity on the relationship between 25-hydroxyvitamin d and adiponectin in caucasian men European Journal of Endocrinology, March 16, 2011
982 Recognition of 5-alpha reductase-2 deficiency in an adult female 46xy dsd clinic European Journal of Endocrinology, March 16, 2011
983 Short stature and metabolic abnormalities in two sisters with a 7.6-kb GH1 gene deletion Growth Hormone & IGF Research, March 16, 2011
984 The severe short stature in two siblings with a heterozygous IGF1 mutation is not caused by a dominant negative effect of the putative truncated protein Growth Hormone & IGF Research, March 16, 2011
985 Acylation stimulating protein: a female lipogenic factor Obesity Reviews, March 16, 2011
986 Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk Metabolism, March 16, 2011
987 Ghrelin neutralization during fasting-refeeding cycle impairs the recuperation of body weight and alters hepatic energy metabolism Molecular and Cellular Endocrinology, March 16, 2011
988 Targeted expression of islet neogenesis associated protein to beta cells enhances glucose tolerance and confers resistance to streptozotocin-induced hyperglycemia Molecular and Cellular Endocrinology, March 16, 2011
989 Stage-specific regulation of juvenile hormone biosynthesis by ecdysteroid in Bombyx mori Molecular and Cellular Endocrinology, March 16, 2011
990 Impaired neonatal survival of pro-opiomelanocortin null mutants Molecular and Cellular Endocrinology, March 16, 2011
991 Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1 Molecular and Cellular Endocrinology, March 16, 2011
992 Regulation of Ca2+-entry in pancreatic alpha-cell line by transient receptor potential melastatin 4 plays a vital role in glucagon release Molecular and Cellular Endocrinology, March 16, 2011
993 Estradiol induces endothelial cell migration and proliferation through estrogen receptor-enhanced RhoA/ROCK pathway Molecular and Cellular Endocrinology, March 16, 2011
994 Acute suppression of apo B secretion by insulin occurs independently of MTP Biochemical and Biophysical Research Communications, March 15, 2011
995 Extracellular matrix and cell signalling – the dynamic cooperation of integrin, proteoglycan and growth factor receptor Journal of Endocrinology, March 15, 2011
996 Implication of the mineralocorticoid axis in rainbow trout osmoregulation during salinity acclimation Journal of Endocrinology, March 15, 2011
997 Rapid non-genomic effects of corticosteroids and their role in the central stress response Journal of Endocrinology, March 15, 2011
998 Expression of Insulinoma-Associated 2 (INSM2) in Pancreatic Islet Cells Is Regulated by the Transcription Factors Ngn3 and NeuroD1 Endocrinology, March 15, 2011
999 Calcitropic Hormones and IGF-I Are Influenced by Dietary Protein Endocrinology, March 15, 2011
1000 Permanent diabetes during the first year of life: multiple gene screening in 54 patients Diabetologia - Clinical and Experimental Diabetes and Metabolism, March 15, 2011
Clinical Pearls in Endocrinology
- Pioglitazone can reduce the risk of conversion of impaired glucose tolerance to type 2 diabetes mellitus by 72%, but it was also associated with significant weight gain and edema
- The most commonly reported adverse event associated with Janumet in the treatment of type 2 diabetes is diarrhea, followed by upper respiratory tract infection and headache
- Maturity-onset diabetes of the young (MODY)3 can be treated with sulfonylureas with excellent results for decades
Highlights in Endocrinology
Regulatory protein identified in T1DM
As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.
Read the article summaryStatins increase risk of DM in postmenopausal women
As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up
Read the article summaryDetermining the basal insulin dosage in T2DM
Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.
Read the article summaryMost Popular Endocrinology Articles
Last month's top read Top Articles of 20121 Genetic Information and the Prediction of Incident Type 2 Diabetes in a High-Risk Multi-Ethnic Population: The EpiDREAM Genetic Study Diabetes Care, April 22, 2013
2 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013
3 Mutations in MCT8 in Patients with Allan-Herndon-Dudley-Syndrome Affecting Its Cellular Distribution Molecular Endocrinology, April 5, 2013 Review Article
4 The use of U-500 regular insulin in the management of patients with obesity and insulin resistance Diabetes, Obesity and Metabolism, March 13, 2013
5 Comparison of Diabetic Ketoacidosis in Patients With Type-1 and Type-2 Diabetes Mellitus The American Journal of the Medical Sciences, April 1, 2013
6 Metabolically healthy polycystic ovary syndrome (MH-PCOS) and metabolically unhealthy polycystic ovary syndrome (MU-PCOS): a comparative analysis of four simple methods useful for metabolic assessment Human Reproduction, April 22, 2013
7 Over-the-Counter-Drug-Induced Thyroid Disorders Endocrine Practice, March 26, 2013 Free full text
8 Serum magnesium in the metabolically-obese normal-weight and healthy-obese subjects European Journal of Internal Medicine , April 17, 2013
9 Prevalence of Unrecognized Diabetes Mellitus in Patients Admitted With Acute Coronary Syndrome Angiology, April 2, 2013
10 Treatment with the long-acting insulin analogues detemir or glargine during pregnancy in women with type 1 diabetes: comparison of glycaemic control and pregnancy outcome The Journal of Maternal-Fetal and Neonatal Medicine, April 3, 2013
11 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, April 9, 2013
12 PROK2/PROKR2 signaling and Kallmann syndrome Frontiers in Endocrinology, April 15, 2013 Review Article
13 The worrisome liaison between left ventricular systolic dysfunction and mitral annulus calcification in type 2 diabetes without coronary artery disease: Data from the SHORTWAVE study Nutrition, Metabolism & Cardiovascular Diseases, April 15, 2013
14 Is Subclinical Hypothyroidism a Cardiovascular Risk Factor in the Elderly? Journal of Clinical Endocrinology and Metabolism, April 5, 2013 Review Article
15 In-treatment HDL cholesterol levels and development of new diabetes mellitus in hypertensive patients: The LIFE Study Diabetic Medicine, April 18, 2013
16 Randomized trial of Metformin versus Insulin in the Management of Gestational Diabetes American Journal of Obstetrics and Gynecology, April 19, 2013
17 Gonadotropin-Releasing Hormone Stimulates the Biosynthesis of Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate in the Hypothalamus Endocrinology, April 24, 2013 Review Article
18 Notch Signaling in Skeletal Health and Disease European Journal of Endocrinology, April 5, 2013 Review Article
19 U-Shape Association Between Hemoglobin A1c and Late Mortality in Patients With Heart Failure After Cardiac Surgery The American Journal of Cardiology, April 5, 2013
20 Emergence of ovulatory cycles with aging in women with polycystic ovary syndrome (PCOS) alters the trajectory of cardiovascular and metabolic risk factors Human Reproduction, April 22, 2013
Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetes more
Other Topics in Endocrinology
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