Endocrinology - Basic Science/Genetics News & Articles

MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.

Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

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21 Common susceptibility alleles and SQSTM1 mutations predict disease extent and severity in a multinational study of patients with Paget's disease Journal of Bone and Mineral Research, May 9, 2013 Review Article

22 Individual multi-locus heterozygosity is associated with lower morning plasma cortisol concentration European Journal of Endocrinology, May 9, 2013 Review Article

23 AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study Diabetes/Metabolism Research and Reviews, May 8, 2013 Evidence Based Medicine

24 The lactase persistence genotype is associated with body mass index and dairy consumption in the D.E.S.I.R. study Metabolism, May 8, 2013 Review Article

25 Robust evidence for five new Grave's disease risk loci from a staged genome-wide association analysis Human Molecular Genetics, May 8, 2013 Review Article

26 Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting Cell Metabolism, May 7, 2013 Review Article

27 Tam41 Is a CDP-Diacylglycerol Synthase Required for Cardiolipin Biosynthesis in Mitochondria Cell Metabolism, May 7, 2013 Review Article

28 Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status Cell Metabolism, May 7, 2013 Review Article

29 No Difference In Phenotype Of The Main Dutch Sdhd Founder Mutations Clinical Endocrinology, May 7, 2013 Review Article

30 The potential for cardiac protection with DPP4 inhibition: the stromal cell-derived factor-1 (SDF-1) hypothesis Journal of Diabetes, May 7, 2013 Review Article

31 Acting on Hormone Receptors with Minimal Side Effect on Cell Proliferation: A Timely Challenge Illustrated with GLP-1R and GPER Frontiers in Endocrinology, May 7, 2013 Review Article

32 Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans Journal of Clinical Endocrinology and Metabolism, May 6, 2013 Review Article

33 BRAF and RAS Mutations in Follicular Variants of Papillary Thyroid Carcinoma Endocrine Pathology, May 6, 2013 Review Article

34 Insulin-Mediated Activation of the L-Arginine Nitric Oxide Pathway in Man, and Its Impairment in Diabetes PLOS ONE, May 6, 2013 Review Article

35 Efatutazone, an Oral PPAR-{gamma} Agonist, in Combination with Paclitaxel in Anaplastic Thyroid Cancer: Results of a Multicenter Phase 1 Trial Journal of Clinical Endocrinology and Metabolism, May 6, 2013 Review Article

36 Identification of a novel androgen receptor mutation in a family with multiple components compatible with the testicular dysgenesis syndrome Journal of Clinical Endocrinology and Metabolism, May 6, 2013 Review Article

37 Histidines in Potential Substrate Recognition Sites Affect Thyroid Hormone Transport by Monocarboxylate Transporter 8 (MCT8) Endocrinology, May 6, 2013 Review Article

38 Preparation of thyroid follicular cells for mRNA quantification after fluorescence-activated cell sorting Scandinavian Journal of Clinical and Laboratory Investigation, May 6, 2013 Review Article

39 Two Novel Functional Single Nucleotide Polymorphisms of ADRB3 Are Associated With Type 2 Diabetes in the Chinese Population Journal of Clinical Endocrinology and Metabolism, May 3, 2013 Review Article

40 Detection and Characterization of Two Novel Mutations in the HNF4A Gene in Maturity-Onset Diabetes of the Young Type 1 in Two Japanese Families Hormone Research in Paediatrics, May 3, 2013 Review Article

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Clinical Pearls in Endocrinology

Pioglitazone can reduce the risk of conversion of impaired glucose tolerance to type 2 diabetes mellitus by 72%, but it was also associated with significant weight gain and edema
The most commonly reported adverse event associated with Janumet in the treatment of type 2 diabetes is diarrhea, followed by upper respiratory tract infection and headache
Maturity-onset diabetes of the young (MODY)3 can be treated with sulfonylureas with excellent results for decades

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Highlights in Endocrinology

Regulatory protein identified in T1DM

As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.

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Statins increase risk of DM in postmenopausal women

As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up

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Determining the basal insulin dosage in T2DM

Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.

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Most Popular Endocrinology Articles

Last month's top read Top Articles of 2012

1 Genetic Information and the Prediction of Incident Type 2 Diabetes in a High-Risk Multi-Ethnic Population: The EpiDREAM Genetic Study Diabetes Care, April 22, 2013

2 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013

3 Mutations in MCT8 in Patients with Allan-Herndon-Dudley-Syndrome Affecting Its Cellular Distribution Molecular Endocrinology, April 5, 2013 Review Article

4 The use of U-500 regular insulin in the management of patients with obesity and insulin resistance Diabetes, Obesity and Metabolism, March 13, 2013

5 Comparison of Diabetic Ketoacidosis in Patients With Type-1 and Type-2 Diabetes Mellitus The American Journal of the Medical Sciences, April 1, 2013

6 Metabolically healthy polycystic ovary syndrome (MH-PCOS) and metabolically unhealthy polycystic ovary syndrome (MU-PCOS): a comparative analysis of four simple methods useful for metabolic assessment Human Reproduction, April 22, 2013

7 Over-the-Counter-Drug-Induced Thyroid Disorders Endocrine Practice, March 26, 2013 Free full text

8 Serum magnesium in the metabolically-obese normal-weight and healthy-obese subjects European Journal of Internal Medicine , April 17, 2013

9 Prevalence of Unrecognized Diabetes Mellitus in Patients Admitted With Acute Coronary Syndrome Angiology, April 2, 2013

10 Treatment with the long-acting insulin analogues detemir or glargine during pregnancy in women with type 1 diabetes: comparison of glycaemic control and pregnancy outcome The Journal of Maternal-Fetal and Neonatal Medicine, April 3, 2013

11 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, April 9, 2013

12 PROK2/PROKR2 signaling and Kallmann syndrome Frontiers in Endocrinology, April 15, 2013 Review Article

13 The worrisome liaison between left ventricular systolic dysfunction and mitral annulus calcification in type 2 diabetes without coronary artery disease: Data from the SHORTWAVE study Nutrition, Metabolism & Cardiovascular Diseases, April 15, 2013

14 Is Subclinical Hypothyroidism a Cardiovascular Risk Factor in the Elderly? Journal of Clinical Endocrinology and Metabolism, April 5, 2013 Review Article

15 In-treatment HDL cholesterol levels and development of new diabetes mellitus in hypertensive patients: The LIFE Study Diabetic Medicine, April 18, 2013

16 Randomized trial of Metformin versus Insulin in the Management of Gestational Diabetes American Journal of Obstetrics and Gynecology, April 19, 2013

17 Gonadotropin-Releasing Hormone Stimulates the Biosynthesis of Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate in the Hypothalamus Endocrinology, April 24, 2013 Review Article

18 Notch Signaling in Skeletal Health and Disease European Journal of Endocrinology, April 5, 2013 Review Article

19 U-Shape Association Between Hemoglobin A1c and Late Mortality in Patients With Heart Failure After Cardiac Surgery The American Journal of Cardiology, April 5, 2013

20 Emergence of ovulatory cycles with aging in women with polycystic ovary syndrome (PCOS) alters the trajectory of cardiovascular and metabolic risk factors Human Reproduction, April 22, 2013

Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetes more

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Endocrinology - Basic Science/Genetics News & Articles

Articles

Clinical Pearls in Endocrinology

Highlights in Endocrinology

Regulatory protein identified in T1DM

Statins increase risk of DM in postmenopausal women

Determining the basal insulin dosage in T2DM

Most Popular Endocrinology Articles

Other Topics in Endocrinology