Endocrinology News & Articles

MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.

Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (50) Full Text Articles (2688) Focus on Atherosclerosis

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

661 Cyclooxygenase 2 Promotes Parathyroid Hyperplasia in ESRD Full Text Journal of the American Society of Nephrology, February 24, 2012 Original Publication Date: February 23, 2011

662 Pregnancy Does Not Accelerate Corticotroph Tumor Progression in Nelson's Syndrome Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

663 1,25-Dihydroxyvitamin D3 Reduces TGF-beta3-Induced Fibrosis-Related Gene Expression in Human Uterine Leiomyoma Cells Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

664 Gonadotropin-Releasing Hormone Agonist Treatment in Postmenopausal Women with Hyperandrogenism of Ovarian Origin Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

665 Neonatal Hyperparathyroidism with a Heterozygous Calcium-Sensing Receptor (CASR) R185Q Mutation: Clinical Benefit from Cinacalcet Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

666 Insulin- and Leptin-Mediated Control of Aquaglyceroporins in Human Adipocytes and Hepatocytes Is Mediated via the PI3K/Akt/mTOR Signaling Cascade Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

667 Correlation of Plasma Copeptin and Vasopressin Concentrations in Hypo-, Iso-, and Hyperosmolar States Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

668 The Akt-Specific Inhibitor MK2206 Selectively Inhibits Thyroid Cancer Cells Harboring Mutations That Can Activate the PI3K/Akt Pathway Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

669 Increased Transactivation Associated with SOX3 Polyalanine Tract Deletion in a Patient with Hypopituitarism Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

670 Impaired CRH and Urocortin Expression and Function in Eutopic Endometrium of Women with Endometriosis Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

671 Somatic Mutation and Germline Sequence Abnormalities in CDKN1B, Encoding p27Kip1, in Sporadic Parathyroid Adenomas Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

672 AMPK-Dependent Phosphorylation of ULK1 Induces Autophagy Full Text Cell Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

673 Adiponectin Receptor Signaling: A New Layer to the Current Model Full Text Cell Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

674 The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1alpha/ATF6alpha Complex Full Text Cell Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

675 Autonomic MC Sets the Metabolic Tone Full Text Cell Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

676 Crosstalk between Components of Circadian and Metabolic Cycles in Mammals Full Text Cell Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

677 A Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory Stress Response to a High-Fat, High-Carbohydrate Meal Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

678 A1C Variability as an Independent Risk Factor for Microalbuminuria in Young People With Type 1 Diabetes Full Text Diabetes Care, February 23, 2012 Original Publication Date: February 22, 2011 Clinical Article

679 Effect of continuous glucose monitoring on hypoglycemia in type 1 diabetes Full Text Diabetes Care, February 23, 2012 Original Publication Date: February 22, 2011

680 Interaction of Onset and Duration of Diabetes on the Percent of GAD Antibody and Insulinoma-Antigen 2 Antibodies-Positive Subjects in the Type 1 Diabetes Genetic Consortium Database Full Text Diabetes Care, February 23, 2012 Original Publication Date: February 22, 2011

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Clinical Pearls in Endocrinology

Pioglitazone can reduce the risk of conversion of impaired glucose tolerance to type 2 diabetes mellitus by 72%, but it was also associated with significant weight gain and edema
The most commonly reported adverse event associated with Janumet in the treatment of type 2 diabetes is diarrhea, followed by upper respiratory tract infection and headache
Maturity-onset diabetes of the young (MODY)3 can be treated with sulfonylureas with excellent results for decades

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Endocrinology

Regulatory protein identified in T1DM

As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.

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Statins increase risk of DM in postmenopausal women

As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up

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Determining the basal insulin dosage in T2DM

Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.

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Most Popular Endocrinology Articles

Last month's top read Top Articles of 2012

1 Over-the-Counter-Drug-Induced Thyroid Disorders Endocrine Practice, March 26, 2013 Free full text

2 Desiccated Thyroid Extract Compared With Levothyroxine in the Treatment of Hypothyroidism: A Randomized, Double-Blind, Crossover Study Journal of Clinical Endocrinology and Metabolism, March 29, 2013

3 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, April 9, 2013

4 Treatment of Diabetic Ketoacidosis (DKA) with 2 Different Regimens Regarding Fluid Substitution and Insulin Dosage (0.025 vs. 0.1 units/kg/h) Experimental and Clinical Endocrinology & Diabetes, February 13, 2012

5 Elevated 1-Hour Postload Plasma Glucose Levels Identify Subjects With Normal Glucose Tolerance but Impaired {beta}-Cell Function, Insulin Resistance, and Worse Cardiovascular Risk Profile: The GENFIEV Study Journal of Clinical Endocrinology and Metabolism, April 5, 2013

6 Very Low Calorie Diet Mimics the Early Beneficial Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity and Beta-Cell Function in Type 2 Diabetic Patients Diabetes, April 24, 2013 Review Article

7 Relationships Between Serum Adiponectin and Bone Density, Adiposity and Calcified Atherosclerotic Plaque in the African American-Diabetes Heart Study Journal of Clinical Endocrinology and Metabolism, April 2, 2013 Review Article

8 Serum uric acid levels and incidence of impaired fasting glucose and type 2 diabetes mellitus: A meta-analysis of cohort studies Diabetes Research and Clinical Practice, April 23, 2013 Evidence Based Medicine

9 A comparison of insulin detemir and neutral protamine Hagedorn (isophane) insulin in the treatment of diabetes: a systematic review Diabetes, Obesity and Metabolism, April 4, 2013 Evidence Based Medicine Review Article

10 Significance of estimating the glomerular filtration rate for the management of hypertension in type 2 diabetes with microalbuminuria Hypertension Research, April 8, 2013

11 Validation of a Novel Method for Determining the Renal Threshold for Glucose Excretion in Untreated and Canagliflozin-treated Subjects With Type 2 Diabetes Mellitus Journal of Clinical Endocrinology and Metabolism, April 15, 2013

12 Guidelines for the use of bone metabolic markers in the diagnosis and treatment of osteoporosis (2012 edition) Journal of Bone and Mineral Metabolism, February 5, 2013 Clinical Guideline

13 Secular Changes in U.S. Prediabetes Prevalence Defined by Hemoglobin A_1c and Fasting Plasma Glucose: National Health and Nutrition Examination Surveys, 1999-2010 Diabetes Care, April 22, 2013

14 Mechanisms of Glucose Lowering of Dipeptidyl Peptidase-4 Inhibitor Sitagliptin When Used Alone or With Metformin in Type 2 Diabetes: A double-tracer study Diabetes Care, April 17, 2013

15 Treatment with the long-acting insulin analogues detemir or glargine during pregnancy in women with type 1 diabetes: comparison of glycaemic control and pregnancy outcome The Journal of Maternal-Fetal and Neonatal Medicine, April 3, 2013

16 Randomized trial of Metformin versus Insulin in the Management of Gestational Diabetes American Journal of Obstetrics and Gynecology, April 19, 2013

17 Effects of patient-tailored atorvastatin therapy on ameliorating the levels of atherogenic lipids and inflammation beyond lowering low-density lipoprotein cholesterol in patients with type 2 diabetes Journal of Diabetes Investigation, April 3, 2013 Review Article

18 Efficacy and safety of linagliptin in type 2 diabetes subjects at high risk for renal and cardiovascular disease: a pooled analysis of six phase III clinical trials Cardiovascular Diabetology, April 12, 2013 Free full text

19 Metformin and Sulfonylureas in Relation to Cancer Risk in Type II Diabetes Patients: A Meta-analysis using primary data of published studies Metabolism, February 19, 2013 Evidence Based Medicine

20 Adding Once-Daily Lixisenatide for Type 2 Diabetes Inadequately Controlled With Newly Initiated and Continuously Titrated Basal Insulin Glargine: A 24-Week, Randomized, Placebo-Controlled Study (GETGOAL-DUO-1) Diabetes Care, April 8, 2013

Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetes more

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Endocrinology News & Articles

Articles

Clinical Pearls in Endocrinology

Highlights in Endocrinology

Regulatory protein identified in T1DM

Statins increase risk of DM in postmenopausal women

Determining the basal insulin dosage in T2DM

Most Popular Endocrinology Articles

Other Topics in Endocrinology