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Endocrinology News & Articles

MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.

Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (61) Full Text Articles (2688) Focus on Pediatrics
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

641 Structural Determinants of Agonist-Selective Signaling at the sst2A Somatostatin Receptor Full Text Molecular Endocrinology, February 25, 2012 Original Publication Date: February 24, 2011

642 Altered AIB1 or AIB13 Expression Impacts ERalpha Effects on Mammary Gland Stromal and Epithelial Content Full Text Molecular Endocrinology, February 25, 2012 Original Publication Date: February 24, 2011

643 FSH and Its Second Messenger cAMP Stimulate the Transcription of Human Anti-Mullerian Hormone in Cultured Granulosa Cells Full Text Molecular Endocrinology, February 25, 2012 Original Publication Date: February 24, 2011

644 Update and Extension of a Glycoprotein Hormone Receptors Web Application Full Text Molecular Endocrinology, February 25, 2012 Original Publication Date: February 24, 2011

645 Reactive Oxygen Species (ROS) Play a Critical Role in the cAMP-Induced Activation of Ras and the Phosphorylation of the ERK1/2 in Leydig Cells Full Text Molecular Endocrinology, February 25, 2012 Original Publication Date: February 24, 2011

646 Species-Specific Strategies Underlying Conserved Functions of Metabolic Transcription Factors Full Text Molecular Endocrinology, February 25, 2012 Original Publication Date: February 24, 2011

647 Multiple Sequence-Specific DNA-Binding Proteins Mediate Estrogen Receptor Signaling through a Tethering Pathway Full Text Molecular Endocrinology, February 25, 2012 Original Publication Date: February 24, 2011

648 Amino Acid-Dependent Activation of Liver Estrogen Receptor Alpha Integrates Metabolic and Reproductive Functions via IGF-1 Full Text Cell Metabolism, February 25, 2012 Original Publication Date: February 24, 2011

649 Molecular Annotation of Integrative Feeding Neural Circuits Full Text Cell Metabolism, February 25, 2012 Original Publication Date: February 24, 2011

650 Exenatide Twice Daily Versus Premixed Insulin Aspart 70/30 in Metformin-Treated Patients With Type 2 Diabetes: A randomized 26-week study on glycemic control and hypoglycemia Full Text Diabetes Care, February 24, 2012 Original Publication Date: February 23, 2011

651 Effects of Denosumab Treatment and Discontinuation on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women with Low Bone Mass Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

652 Osteoporosis Medication and Reduced Mortality Risk in Elderly Women and Men Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

653 Progestogen-Only Contraceptives and the Risk of Acute Myocardial Infarction: A Meta-Analysis Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011    Evidence Based Medicine

654 Chronically Increased S6K1 Is Associated with Impaired IRS1 Signaling in Skeletal Muscle of GDM Women with Impaired Glucose Tolerance Postpartum Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

655 Effects of Two Selective Serotonin Reuptake Inhibitor Antidepressants, Sertraline and Escitalopram, on Aldosterone/Renin Ratio in Normotensive Depressed Male Patients Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

656 Progressive Hyperglycemia across the Glucose Tolerance Continuum in Older Obese Adults Is Related to Skeletal Muscle Capillarization and Nitric Oxide Bioavailability Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

657 Stimulation of Human Whole-Body Energy Expenditure by Salsalate Is Fueled by Higher Lipid Oxidation under Fasting Conditions and by Higher Oxidative Glucose Disposal under Insulin-Stimulated Conditions Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

658 Postnatal Decrease in Circulating Insulin-Like Growth Factor-I and Low Brain Volumes in Very Preterm Infants Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

659 Higher Serum Free Testosterone Concentration in Older Women Is Associated with Greater Bone Mineral Density, Lean Body Mass, and Total Fat Mass: the Cardiovascular Health Study Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

660 The Effect of Gonadotropin Withdrawal and Stimulation with Human Chorionic Gonadotropin on Intratesticular Androstenedione and DHEA in Normal Men Full Text Journal of Clinical Endocrinology and Metabolism, February 24, 2012 Original Publication Date: February 23, 2011

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Clinical Pearls in Endocrinology

Highlights in Endocrinology

Regulatory protein identified in T1DM

As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.

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Statins increase risk of DM in postmenopausal women

As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up

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Determining the basal insulin dosage in T2DM

Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.

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Most Popular Endocrinology Articles

Last month's top read Top Articles of 2012

1 Diet beverages and the risk of obesity, diabetes, and cardiovascular disease: a review of the evidence Nutrition Reviews, May 7, 2013    Review Article

2 Treatment of Diabetic Ketoacidosis (DKA) with 2 Different Regimens Regarding Fluid Substitution and Insulin Dosage (0.025 vs. 0.1 units/kg/h) Experimental and Clinical Endocrinology & Diabetes, February 13, 2012

3 A 7-year follow-up retrospective, international, multicenter study of insulin pump therapy in children and adolescents with type 1 diabetes Acta Diabetologia, May 17, 2013    Review Article
Exclusive Author Commentary

4 Randomized Trial of Continuous Subcutaneous Delivery of Exenatide by ITCA 650 Versus Twice-Daily Exenatide Injections in Metformin-Treated Type 2 Diabetes Diabetes Care, May 6, 2013

5 Desiccated Thyroid Extract Compared With Levothyroxine in the Treatment of Hypothyroidism: A Randomized, Double-Blind, Crossover Study Journal of Clinical Endocrinology and Metabolism, March 29, 2013

6 Mortality outcomes of different sulfonylurea drugs. The results of a 14-year cohort study of type 2 diabetic patients European Journal of Endocrinology, May 13, 2013

7 Over-the-Counter-Drug-Induced Thyroid Disorders Endocrine Practice, March 26, 2013    Free full text

8 Characteristics Associated With Maintenance of Mean A1C <6.5% in People With Dysglycemia in the ORIGIN Trial Diabetes Care, May 10, 2013

9 Adding Once-Daily Lixisenatide for Type 2 Diabetes Inadequately Controlled by Established Basal Insulin: A 24-week, randomized, placebo-controlled comparison (GetGoal-L) Diabetes Care, May 8, 2013

10 Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (getgoal-x) Diabetes Care, May 24, 2013

11 Effects of exercise training on quality of life, symptoms of depression, symptoms of anxiety and emotional well-being in type 2 diabetes mellitus: a systematic review Diabetologia - Clinical and Experimental Diabetes and Metabolism, May 13, 2013    Evidence Based Medicine    Review Article

12 The Biopsy-Proven Benign Thyroid Nodule: Is Long-Term Follow-Up Necessary? Journal of the American College of Surgeons, May 14, 2013

13 Adding Once-Daily Lixisenatide for Type 2 Diabetes Inadequately Controlled by Established Basal Insulin: A 24-week, randomized, placebo-controlled comparison (GetGoal-l) Diabetes Care, May 1, 2013

14 Role of HDL cholesterol and estimates of HDL particle composition in future development of type 2 diabetes in the general population: The PREVEND Study Journal of Clinical Endocrinology and Metabolism, May 21, 2013

15 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, April 9, 2013

16 Obesity and the Food Environment: Income and Ethnicity Differences Among People With Diabetes: The Diabetes Study of Northern California (DISTANCE) Diabetes Care, May 3, 2013    Review Article

17 The Osteocyte: An Endocrine Cell and More Endocrine Reviews, May 17, 2013    Review Article

18 Very Low Calorie Diet Mimics the Early Beneficial Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity and Beta-Cell Function in Type 2 Diabetic Patients Diabetes, April 24, 2013    Review Article

19 High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial European Journal of Nutrition, May 29, 2013

20 Serum uric acid levels and incidence of impaired fasting glucose and type 2 diabetes mellitus: A meta-analysis of cohort studies Diabetes Research and Clinical Practice, April 23, 2013    Evidence Based Medicine

Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetesmore

Other Topics in Endocrinology

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