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Endocrinology News & Articles
MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
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Articles
Latest (51) Full Text Articles (2688) Focus on Diabetes41 One-Hour Postload Plasma Glucose Levels and Diastolic Function in Hypertensive Patients Full Text Diabetes Care, October 1, 2012 Original Publication Date: September 30, 2011
42 Exploring the understanding of evidence-based concepts in people with type 2 diabetes Full Text International Journal of General Medicine, October 1, 2012
43 Baroreflex Sensitivity and Its Response to Deep Breathing Predict Increase in Blood Pressure in Type 1 Diabetes in a 5-Year Follow-Up Full Text Diabetes Care, October 1, 2012 Original Publication Date: September 30, 2011
44 Prospectively Determined Impact of Type 1 Diabetes on Brain Volume During Development Full Text Diabetes, October 1, 2012 Original Publication Date: September 30, 2011
45 Low Glycated Hemoglobin and Liver Disease in the U.S. Population Full Text Diabetes Care, September 30, 2012 Original Publication Date: September 29, 2011
46 Optimizing Insulin Glargine Plus One Injection of Insulin Glulisine in Type 2 Diabetes in the ELEONOR Study Full Text Diabetes Care, September 30, 2012 Original Publication Date: September 29, 2011 Clinical Article
47 Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes Full Text New England Journal of Medicine, September 30, 2012 Original Publication Date: March 29, 2012
48 Evaluation of Nonfasting Tests to Screen for Childhood and Adolescent Dysglycemia Full Text Diabetes Care, September 30, 2012 Original Publication Date: September 29, 2011
49 Depressive Symptoms, Antidepressant Medication Use, and Insulin Resistance : The PPP-Botnia Study Full Text Diabetes Care, September 30, 2012 Original Publication Date: September 29, 2011
50 Insulin Resistance Is Associated With a Poor Response to Intravenous Thrombolysis in Acute Ischemic Stroke Full Text Diabetes Care, September 30, 2012 Original Publication Date: September 29, 2011
51 Plasma sterol evidence for decreased absorption and increased synthesis of cholesterol in insulin resistance and obesity Full Text American Journal of Clinical Nutrition, September 30, 2012 Original Publication Date: September 29, 2011
52 Associations Between Paternally Transmitted Fetal IGF2 Variants and Maternal Circulating Glucose Concentrations in Pregnancy Full Text Diabetes, September 30, 2012 Original Publication Date: September 29, 2011
53 Sensor-Augmented Pump Therapy for A1C Reduction (STAR 3) Study: Results from the 6-month continuation phase Full Text Diabetes Care, September 29, 2012 Original Publication Date: September 28, 2011 Clinical Article
54 Vorapaxar in the Secondary Prevention of Atherothrombotic Events Full Text New England Journal of Medicine, September 29, 2012 Original Publication Date: March 28, 2012 Clinical Article
55 Elevated NF-{kappa}B Activation Is Conserved in Human Myocytes Cultured From Obese Type 2 Diabetic Patients and Attenuated by AMP-Activated Protein Kinase Full Text Diabetes, September 29, 2012 Original Publication Date: September 28, 2011
56 C-Peptide Response and HLA Genotypes in Subjects With Recent-Onset Type 1 Diabetes After Immunotherapy With DiaPep277 An Exploratory Study Full Text Diabetes, September 29, 2012 Original Publication Date: September 28, 2011
57 Elevated Depressive Symptoms, Antidepressant Use, and Diabetes in a Large Multiethnic National Sample of Postmenopausal Women Full Text Diabetes Care, September 29, 2012 Original Publication Date: September 28, 2011
58 Dose Response to Vitamin D Supplementation in Postmenopausal Women Full Text Annals of Internal Medicine, September 28, 2012 Original Publication Date: March 27, 2012
59 Encounter Frequency and Serum Glucose Level, Blood Pressure, and Cholesterol Level Control in Patients With Diabetes Mellitus Full Text Archives of Internal Medicine, September 28, 2012 Original Publication Date: September 27, 2011 Clinical Article
60 Childhood and family influences on body mass index in early adulthood: findings from the Ontario Child Health Study Full Text BMC Public Health, September 28, 2012
Clinical Pearls in Endocrinology
- Pioglitazone can reduce the risk of conversion of impaired glucose tolerance to type 2 diabetes mellitus by 72%, but it was also associated with significant weight gain and edema
- The most commonly reported adverse event associated with Janumet in the treatment of type 2 diabetes is diarrhea, followed by upper respiratory tract infection and headache
- Maturity-onset diabetes of the young (MODY)3 can be treated with sulfonylureas with excellent results for decades
Highlights in Endocrinology
Regulatory protein identified in T1DM
As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.
Read the article summaryStatins increase risk of DM in postmenopausal women
As reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up
Read the article summaryDetermining the basal insulin dosage in T2DM
Anthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.
Read the article summaryMost Popular Endocrinology Articles
Last month's top read Top Articles of 20121 Over-the-Counter-Drug-Induced Thyroid Disorders Endocrine Practice, March 26, 2013 Free full text
2 Desiccated Thyroid Extract Compared With Levothyroxine in the Treatment of Hypothyroidism: A Randomized, Double-Blind, Crossover Study Journal of Clinical Endocrinology and Metabolism, March 29, 2013
3 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, April 9, 2013
4 Treatment of Diabetic Ketoacidosis (DKA) with 2 Different Regimens Regarding Fluid Substitution and Insulin Dosage (0.025 vs. 0.1 units/kg/h) Experimental and Clinical Endocrinology & Diabetes, February 13, 2012
5 Elevated 1-Hour Postload Plasma Glucose Levels Identify Subjects With Normal Glucose Tolerance but Impaired {beta}-Cell Function, Insulin Resistance, and Worse Cardiovascular Risk Profile: The GENFIEV Study Journal of Clinical Endocrinology and Metabolism, April 5, 2013
6 Very Low Calorie Diet Mimics the Early Beneficial Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity and Beta-Cell Function in Type 2 Diabetic Patients Diabetes, April 24, 2013 Review Article
7 Relationships Between Serum Adiponectin and Bone Density, Adiposity and Calcified Atherosclerotic Plaque in the African American-Diabetes Heart Study Journal of Clinical Endocrinology and Metabolism, April 2, 2013 Review Article
8 Serum uric acid levels and incidence of impaired fasting glucose and type 2 diabetes mellitus: A meta-analysis of cohort studies Diabetes Research and Clinical Practice, April 23, 2013 Evidence Based Medicine
9 A comparison of insulin detemir and neutral protamine Hagedorn (isophane) insulin in the treatment of diabetes: a systematic review Diabetes, Obesity and Metabolism, April 4, 2013 Evidence Based Medicine Review Article
10 Significance of estimating the glomerular filtration rate for the management of hypertension in type 2 diabetes with microalbuminuria Hypertension Research, April 8, 2013
11 Validation of a Novel Method for Determining the Renal Threshold for Glucose Excretion in Untreated and Canagliflozin-treated Subjects With Type 2 Diabetes Mellitus Journal of Clinical Endocrinology and Metabolism, April 15, 2013
12 Guidelines for the use of bone metabolic markers in the diagnosis and treatment of osteoporosis (2012 edition) Journal of Bone and Mineral Metabolism, February 5, 2013 Clinical Guideline
13 Secular Changes in U.S. Prediabetes Prevalence Defined by Hemoglobin A1c and Fasting Plasma Glucose: National Health and Nutrition Examination Surveys, 1999-2010 Diabetes Care, April 22, 2013
14 Mechanisms of Glucose Lowering of Dipeptidyl Peptidase-4 Inhibitor Sitagliptin When Used Alone or With Metformin in Type 2 Diabetes: A double-tracer study Diabetes Care, April 17, 2013
15 Treatment with the long-acting insulin analogues detemir or glargine during pregnancy in women with type 1 diabetes: comparison of glycaemic control and pregnancy outcome The Journal of Maternal-Fetal and Neonatal Medicine, April 3, 2013
16 Randomized trial of Metformin versus Insulin in the Management of Gestational Diabetes American Journal of Obstetrics and Gynecology, April 19, 2013
17 Effects of patient-tailored atorvastatin therapy on ameliorating the levels of atherogenic lipids and inflammation beyond lowering low-density lipoprotein cholesterol in patients with type 2 diabetes Journal of Diabetes Investigation, April 3, 2013 Review Article
18 Efficacy and safety of linagliptin in type 2 diabetes subjects at high risk for renal and cardiovascular disease: a pooled analysis of six phase III clinical trials Cardiovascular Diabetology, April 12, 2013 Free full text
19 Metformin and Sulfonylureas in Relation to Cancer Risk in Type II Diabetes Patients: A Meta-analysis using primary data of published studies Metabolism, February 19, 2013 Evidence Based Medicine
20 Adding Once-Daily Lixisenatide for Type 2 Diabetes Inadequately Controlled With Newly Initiated and Continuously Titrated Basal Insulin Glargine: A 24-Week, Randomized, Placebo-Controlled Study (GETGOAL-DUO-1) Diabetes Care, April 8, 2013
Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetes more
Other Topics in Endocrinology
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