We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Reactivity to N-terminally truncated GAD65(96-585) identifies GAD autoantibodies that are more closely associated with diabetes progression in relatives of patients with type 1 diabetesDiabetes, May 27, 2015  Clinical Article
2Effects of a Topical Saffron (Crocus sativus L) Gel on Erectile Dysfunction in Diabetics : A Randomized, Parallel-Group, Double-Blind, Placebo-Controlled TrialJournal of Evidence-Based Complementary & Alternative Medicine, May 27, 2015  Clinical Article
3The role of social support on the relationship of depressive symptoms to medication adherence and self-care activities in adults with type 2 diabetesJournal of Advanced Nursing, May 27, 2015  Clinical Article
4Postprandial incretin and islet hormone responses and dipeptidyl-peptidase 4 enzymatic activity in patients with maturity onset diabetes of the youngEuropean Journal of Endocrinology, May 27, 2015  Clinical Article
5Insulin resistance and risk of cardiovascular disease in postmenopausal women: A cohort study from the women's health initiativeCirculation: Cardiovascular Quality and Outcomes, May 27, 2015  Clinical Article
6Circulating IGF-I and IGFBP-3 in relation to the development of β-cell autoimmunity in young childrenEuropean Journal of Endocrinology, May 27, 2015  Clinical Article
7Analysis of insulin pump settings in children and adolescents with type 1 diabetes mellitusPediatric Diabetes, May 27, 2015  Clinical Article
8Macular morphologic findings on optical coherence tomography after microincision vitrectomy for proliferative diabetic retinopathyJapanese Journal of Ophthalmology, May 27, 2015  Clinical Article
9Diabetes and risk of frailty and its potential mechanisms: a prospective cohort study of older adultsJournal of the American Medical Directors Association, May 27, 2015  Clinical Article
10Prediction of mortality by stress echocardiography in 2835 diabetic and 11305 nondiabetic patientsCirculation: Cardiovascular Imaging, May 27, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Researchers identify mechanisms linking early adversity, disease later in lifeUniversity of Georgia Research News, May 27, 2015
2Obese male mice produce more disease-promoting immune cells than femalesUniversity of Michigan Health System, May 27, 2015
3UCLA study finds cells that become sperm or eggs in humans are vulnerable during pregnancyUCLA Health System, May 26, 2015
4Faster heart rate linked to diabetes riskPennsylvania State University Health and Medicine News, May 26, 2015
5Study suggests new way of preventing diabetes-associated blindnessJohns Hopkins Medicine, May 26, 2015
6Maternal obesity compromises babies’ immune system at time of birthThe University of California, Riverside Health News, May 22, 2015
7Studies demonstrate risks, benefits of testosterone therapyAmerican Urological Association News, May 22, 2015
8Massey researcher leads task force to develop first guidelines for pediatric thyroid cancerVirginia Commonwealth University News, May 22, 2015
9Risk of sudden deafness shown to be higher in people with osteoporosisInternational Osteoporosis Foundation News, May 22, 2015
10Fetal gender provides clues for the risk of diabetes in women during and after pregnancyLunenfeld-Tanenbaum Research Institute News, May 22, 2015

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Low vitamin D levels increase risk of GDM

As reported in Acta Diabetologica, the OR for developing gestational diabetes mellitus was 1.48 for each 1 SD decrease in the 25OHD level. A decrease in 25OHD was also shown to be associated with increased insulin resistance in the second trimester.

Vildegliptin superior to glimepiride when added to metformin

As reported in Metabolism, addition of vildegliptin (50 mg bid) to metformin in T2DM patients inadequately controlled on metformin alone was superior to the addition of glimepiride (2 mg tid) to metformin. Patients on the vildegliptin + metformin regimen lost more weight, had an improved lipid profile, had increased insulin sensitivity, and decreased post-prandial lipemia and insulinemia compared to patients on the glimepiride + metformin regimen.

Parenteral vitamin D improves insulin sensitivity

As reported in Swiss Medical Weekly, supplemental vitamin D3 (300,000 IU im) in patients (n=55) with T2DM of > 10 y duration resulted in a 12.8% decrease in HOMA-IR at 6 months compared to an increase of 10% in patients who received placebo.

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Clinical Pearls

Clinical Pearl from Smartest DocChildren born by C-section are at higher risk of developing obesity in childhood.

Clinical Pearl from Smartest DocDiabetes remission rate at 15 years post bariatric surgery is 31%.

Clinical Pearl from Smartest DocBariatric surgery is associated with a 67% reduction in all-cause mortality in obese patients with type 2 diabetes.

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