The Latest Clinical Articles in Endocrinology & Diabetes

1Efficacy and safety of linagliptin co-administered with low-dose metformin once daily versus high-dose metformin twice daily in treatment-naïve patients with type 2 diabetes: a double-blind randomized trialAdvances in Therapy, March 31, 2015  Clinical Article
2The association between glucose-lowering drug use and mortality among breast cancer patients with type 2 diabetesBreast Cancer Research and Treatment, March 31, 2015  Clinical Article
3The role of preanalytical glycolysis in the diagnosis of gestational diabetes mellitus in obese womenAmerican Journal of Obstetrics and Gynecology, March 31, 2015  Clinical Article
4Factors associated with untreated diabetes: analysis of data from 20,496 participants in the Japanese National Health and Nutrition SurveyPLOS ONE, March 31, 2015  Clinical Article
5The association between diabetes and breast cancer stage at diagnosis: a population-based studyBreast Cancer Research and Treatment, March 31, 2015  Clinical Article
6Pancreatic cancer-associated diabetes is an “Exosomopathy”Clinical Cancer Research, March 31, 2015  Review Article
7The influence of familial predisposition to cardiovascular complications upon childhood obesity treatmentPLOS ONE, March 31, 2015  Clinical Article
8Pilot study of exercise therapy on painful diabetic peripheral neuropathyPain Medicine, March 31, 2015  Clinical Article
9Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational statusBMC Cancer, March 31, 2015  Full Text  Clinical Article
10A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial complex I genes in oncocytic thyroid tumorsBMC Cancer, March 31, 2015  Full Text  Clinical Article
1New study links urinary troubles at menopause with sleep, body fat, reaction timeThe North American Menopause Society News, March 31, 2015
2MAIT cell alterations involved in obesity and T2 diabetesCentre National de la Recherche Scientifique News, March 31, 2015
3IMRIC scientists find a surprising link between weaning and glucose metabolism, with implications for diabetes and cell regenerationThe Hebrew University of Jerusalem News, March 31, 2015
4Can our bones protect us against diabetes and obesity?Institut de recherches cliniques de Montréal News, March 31, 2015
5New study: Many diabetes patients with multiple comorbidities don’t get the best possible careTufts Medical Center News, March 31, 2015
6FDA approves new treatment for diabetic retinopathy in patients with diabetic macular edemaFDA Press Announcements, March 31, 2015
7Researchers reverse type 2 diabetes and fatty liver diseaseUniversity of Copenhagen Faculty of Health and Medical Sciences News, March 30, 2015
8Study suggests precision medicine for adrenal cancerUniversity of Michigan Health System, March 30, 2015
9Danish Researchers' breakthrough identification of important proteinUniversity of Copenhagen Faculty of Health and Medical Sciences News, March 30, 2015
10Weight discrimination has major impact on quality of lifeUniversity College London New, March 30, 2015

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Hypoglycemia in hospitalized diabetics and increased mortality

As reported in Endocrine Practice, hospitalized diabetics with secondary hypoglycemia (n=46408) are at increased risk for mortality (OR=1.24), early readmission (OR=1.20), and increased length of stay (OR=1.24) compared to hospitalized diabetics without hypoglycemic episodes.

Decreased survival in diabetic patients with pancreatic cancer

As reported in the British Journal of Cancer, patients with diabetes (n=62) are at increased risk of death from pancreatic cancer overall (HR=1.52) and within 3 years of diagnosis (HR=1.45).

Parenteral vitamin D improves insulin sensitivity

As reported in Swiss Medical Weekly, supplemental vitamin D3 (300,000 IU im) in patients (n=55) with T2DM of > 10 y duration resulted in a 12.8% decrease in HOMA-IR at 6 months compared to an increase of 10% in patients who received placebo.

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Clinical Pearl from Smartest DocType 2 diabetes is associated with an increased risk of developing herpes zoster.

Clinical Pearl from Smartest DocWeight loss of 2.5 - 5.5 kg reduces to the risk of type 2 diabetes by 30% - 60% in obese adults.

Clinical Pearl from Smartest DocAPOL1 nephropathy variants associate with lower levels of subclinical atherosclerosis and reduced risk of death in African Americans with type 2 diabetes.

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