Periodontal disease and type 2 diabetes mellitus: Is the HMGB1–RAGE axis the missing link?
Medical Hypotheses, 08/01/2012
Morimoto–Yamashita Y et al. – Authros recently reported that HMGB1 expression in periodontal tissues was elevated in patients with severe periodontitis. In addition, the receptor for advanced glycation end–products (RAGE), a receptor for HMGB1, was strongly expressed in gingival tissues obtained from patients with type 2 diabetes and periodontitis compared with systemically healthy patients with chronic periodontitis patients. From these data, authors hypothesize that HMGB1 might play a role in the development of diabetes–associated periodontitis.