The Effect of Maternal Obesity on Pregnancy Outcomes of Women with Gestational Diabetes Controlled with Diet Only, Glyburide, or Insulin
American Journal of Perinatology, 07/02/2012
Joy S et al. – Obesity adversely affects pregnancy outcome in women with gestational diabetes mellitus (GDM). Higher rates of pregnancy–related hypertension and hyperbilirubinemia were observed in pregnant women receiving glyburide.
Methods- Women with singleton gestations enrolled for outpatient services diagnosed with GDM and without history of pregnancy-related hypertension at enrollment or in a prior pregnancy were identified in a database.
- Women with GDM controlled by diet only (n = 3918), glyburide (n = 873), or insulin without prior exposure to oral hypoglycemic agents (n = 2229) were included.
- Pregnancy outcomes were compared for obese versus nonobese women within each treatment group and also compared across treatment groups within the obese and nonobese populations.
- Within each treatment group, obesity was associated with higher rates of cesarean delivery, pregnancy-related hypertension, macrosomia, and hyperbilirubinemia (all p < 0.05).
- Higher rates of pregnancy-related hypertension and hyperbilirubinemia were observed in women receiving glyburide.
