Effects of vitamin E on bone turnover markers among US postmenopausal women
Journal of Bone and Mineral Research,  Clinical Article

Hamidi MS et al. – The authors hypothesize that gamma–tocopherol may uncouple bone turnover, resulting in more bone formation than resorption. Vitamin E supplements in the form of alpha–tocopherol suppress serum gamma–tocopherol levels and may have negative effects on bone formation.

Methods
  • They examined the associations between dietary and total (diet and supplements) alpha–tocopherol intake, serum alpha–tocopherol and gamma–tocopherol levels and their ratio, and bone turnover markers (BTMs) among postmenopausal women aged ≥45 years.
  • They used cross–sectional data from the National Health and Nutrition Examination Survey 1999–2002.
  • Multiple regression models with adjustments for relevant confounders were used to examine the associations between intake and serum levels of tocopherols, and serum bone–specific alkaline phosphatase (BAP), a biomarker of bone formation, and urinary N–telopeptides/creatinine (uNTx/Cr), a biomarker of bone resorption.
  • The study sample included 497 postmenopausal women who were not taking estrogen, steroids, or osteoporosis medications, were free from kidney and liver disease, cancer, and rheumatoid arthritis, and were fasting >9 hours prior to examination.

Results
  • Participants had a mean age of 65.5 ± 0.6 years and over 45% used vitamin E (alpha–tocopherol) supplements in the past month.
  • Vitamin E supplement users had significantly lower serum gamma–tocopherol, higher serum alpha–tocopherol levels, and higher ratio of serum alpha–tocopherol to gamma–tocopherol than nonusers.
  • High serum gamma–tocopherol levels and low ratio of serum alpha–tocopherol to gamma–tocopherol were associated with increased BAP levels (p < 0.01 for both).
  • There were no associations between any of the vitamin E variables and uNTx/Cr.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Endocrinology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

<

Most Popular Endocrinology Articles

1 Womens age at first menstrual cycle linked to heart disease risk American Heart Association News, December 16, 2014

2 Metformin for primary colorectal cancer prevention in patients with diabetes: A case-control study in a US population Cancer, December 2, 2014    Clinical Article

3 Brown fat could help manage type 2 diabetes Monash University News, December 1, 2014

4 Association between sugar-sweetened beverages and type 2 diabetes: a meta-analysis Journal of Diabetes Investigation, November 13, 2014    Evidence Based Medicine    Review Article

5 Glucose-lowering with exogenous insulin monotherapy in type 2 diabetes: dose association with all-cause mortality, cardiovascular events, and incident cancer Diabetes, Obesity and Metabolism, December 8, 2014    Clinical Article

6 Comparing dosing of basal insulin analogues detemir and glargine: Is it really unit-per-unit and dose-per-dose? Annals of Pharmacotherapy, March 12, 2014    Clinical Article

7 Association between hemoglobin A1c and all-cause mortality: results of the mortality follow-up of the German National Health Interview and Examination Survey 1998 Diabetes Care, December 9, 2014    Clinical Article

8 Ultrasound-guided thyroid nodule biopsy: outcomes and correlation with imaging features Clinical Imaging, November 24, 2014    Clinical Article

9 Liraglutide and the preservation of pancreatic β-cell function in early type 2 diabetes: The LIBRA Trial Diabetes Care, September 26, 2014    Clinical Article

10 Diabetes in midlife linked to significant cognitive decline 20 years later Johns Hopkins Bloomberg School of Public Health, December 4, 2014

11 Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study American Journal of Clinical Nutrition, December 1, 2014    Evidence Based Medicine    Clinical Article

12 The effect of proton pump inhibitors on glycated hemoglobin levels in patients with type 2 diabetes mellitus Canadian Journal of Diabetes, October 28, 2014    Review Article

13 Effects of 12 weeks high-dose vitamin D3 treatment on insulin sensitivity, beta cell function, and metabolic markers in patients with type 2 diabetes and vitamin D insufficiency – A double-blind, randomized, placebo-controlled trial Metabolism, July 9, 2014    Clinical Article

14 Relationship of glycated hemoglobin A1c, coronary artery calcification and insulin resistance in males without diabetes Archives of Medical Research, December 3, 2014    Clinical Article

15 Efficacy and safety of canagliflozin, an inhibitor of sodium glucose cotransporter 2, when used in conjunction with insulin therapy in patients with type 2 diabetes Diabetes Care, December 12, 2014    Clinical Article

16 Initial combination therapy with metformin/pioglitazone/exenatide is more effective than sequential add-on therapy in subjects with new onset diabetes. results from the efficacy and durability of initial combination therapy for type 2 diabetes (EDICT): a randomized trial Diabetes, Obesity and Metabolism, December 16, 2014    Clinical Article

17 Clinical course and outcomes of type-2 diabetic patients after treatment intensification for insufficient glycaemic control - results of the 2 year prospective DiaRegis follow-up Full Text BMC Cardiovascular Disorders, November 26, 2014    Free full text    Clinical Article

18 TSH suppression post-therapy in Graves' disease: A systematic review on pathophysiology and clinical data Canadian Journal of Diabetes, November 6, 2014    Evidence Based Medicine    Review Article

19 Type 2 diabetes may lead to short-term memory loss University of Houston News, November 21, 2014

20 Can people with type 2 diabetes live longer than people without diabetes? A comparison of all-cause mortality in people initiated with metformin monotherapy or sulfonylurea monotherapy and matched controls without diabetes Diabetes, Obesity and Metabolism, July 11, 2014    Clinical Article

Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetesmore

Make smarter career moves with less time.

Sign up for our free job placement service today and have a dedicated career consultant help locate the right physician job for you!
Click Here for more information.

Get Started Now!

Free-of-charge, no obligation.

Terms and Conditions For M3 Career Consult

By registering with the M3 Career Consult service you authorize M3 USA Corporation to represent you in your job search. The following is a summary of the terms of our service and our mutual obligations to help you find a job:

  • You designate M3 to act as your agent and represent you in your job search;
  • You will not pay us for this service
  • You will advise us of any companies or positions to which you apply or have applied;
  • You will advise us if you believe you are not capable of performing a position for which we submit you, or for which you interview;
  • You will keep all information we provide you about companies or positions strictly confidential;
  • You will promptly provide us with information we request of you;
  • You will make yourself reasonably available for phone, video and in-person conversations and interviews;
  • You will be truthful in all of your communications with us; and
  • You will advise us if anything above changes.
 

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List