PER1 Modulates SGLT1 Transcription In Vitro Independent of E-box Status

Digestive Diseases and Sciences, 05/07/2012

The findings suggest that PER1 exerts an indirect suppressive effect on SGLT1, possibly acting via other clock–controlled genes binding to non–E–box sites on the SGLT1 promoter. Understanding the regulation of rhythmicity of SGLT1 may lead to new treatments for the modulation of SGLT1 expression in conditions such as malabsorption, diabetes, and obesity.

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