Evaluation of 1,5-anhydroglucitol, hemoglobin A1c, and glucose levels in youth and young adults with type 1 diabetes and healthy controls
Pediatric Diabetes, 04/20/2012
Mehta SN et al. – Youth and young adults with T1D demonstrate similar 1,5–AG levels which are distinct from controls. 1,5–AG assessment may provide unique information beyond that provided by HbA1c in the mid–term assessment of glycemic control in young patients with type 1 diabetes (T1D) and HbA1c < 8%.Methods
- The authors compared 1,5-AG, HbA1c, and plasma glucose levels in 138 patients with T1D and 136 healthy controls, aged 10–30 yr.
- Within each group, they investigated associations between 1,5-AG and clinical characteristics, HbA1c and random plasma glucose.
- For patients with T1D, 1,5-AG was further analyzed according to HbA1c strata: <8, 8–9, and >9%.
- Compared to controls, patients with T1D had higher HbA1c, lower 1,5-AG, and higher glucose.
- Males had higher 1,5-AG than females within patients and controls.
- 1,5-AG was not correlated with glucose in either group. 1,5-AG was significantly correlated to HbA1c in patients, but not controls.