mdlinx mdlinx
Latest (50) Full Text Articles (2688) Focus on Obesity Article Summary

Dose-Ranging Effects of Canagliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, as Add-On to Metformin in Subjects With Type 2 Diabetes Full Text
Diabetes Care,  Clinical Article

Rosenstock J et al. – Canagliflozin added onto metformin significantly improved glycemic control in type 2 diabetes and was associated with low incidence of hypoglycemia and significant weight loss. The safety/tolerability profile of canagliflozin was favorable except for increased frequency of genital infections in females.

Methods
  • This was a double-blind, placebo-controlled, parallel-group, multicenter, dose-ranging study in 451 subjects randomized to canagliflozin 50, 100, 200, or 300 mg once daily (QD) or 300 mg twice daily (BID), sitagliptin 100 mg QD, or placebo.
  • Primary end point was change in A1C from baseline through week 12.
  • Secondary end points included change in fasting plasma glucose (FPG), body weight, and overnight urinary glucose-to-creatinine ratio. Safety and tolerability were also assessed.

Results
  • Canagliflozin was associated with significant reductions in A1C from baseline (7.6–8.0%) to week 12: -0.79, -0.76, -0.70, -0.92, and -0.95% for canagliflozin 50, 100, 200, 300 mg QD and 300 mg BID, respectively, versus -0.22% for placebo (all P < 0.001) and -0.74% for sitagliptin.
  • FPG was reduced by -16 to -27 mg/dL, and body weight was reduced by -2.3 to -3.4%, with significant increases in urinary glucose-to-creatinine ratio.
  • Adverse events were transient, mild to moderate, and balanced across arms except for a non–dose-dependent increase in symptomatic genital infections with canagliflozin (3–8%) versus placebo and sitagliptin (2%).
  • Urinary tract infections were reported without dose dependency in 3–9% of canagliflozin, 6% of placebo, and 2% of sitagliptin arms.
  • Overall incidence of hypoglycemia was low.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access Full Text, PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Endocrinology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Endocrinology Articles

Last month's top read Top Articles of 2013

1 Visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors Journal of Neuro-Oncology, March 4, 2014    Clinical Article

2 Glycation of apolipoprotein C1 impairs its CETP inhibitory property: pathophysiological relevance in patients with type 1 and type 2 diabetes Diabetes Care, March 4, 2014    Clinical Article

3 Low carbohydrate diet to achieve weight loss and improve HbA1c in type 2 diabetes and pre-diabetes: experience from one general practice Practical Diabetes, March 17, 2014    Clinical Article

4 Adding glimepiride to current insulin therapy increases high-molecular weight adiponectin levels to improve glycemic control in poorly controlled type 2 diabetes Full Text Diabetology & Metabolic Syndrome, March 28, 2014    Free full text    Clinical Article

5 Imaging characteristics of pathologically proven thymic hyperplasia: identifying features that can differentiate true from lymphoid hyperplasia American Journal of Roentgenology, March 4, 2014    Clinical Article

6 Safety and efficacy of biphasic insulin aspart 30 in type 2 diabetes patients switched from either biphasic or basal human insulin: results from the Gulf cohort of the A1chieve study International Journal of Clinical Practice, March 12, 2014    Clinical Article

7 Association of serum concentration of TNFR1 with all-cause mortality in patients with type 2 diabetes and chronic kidney disease: follow-up of the SURDIAGENE cohort Diabetes Care, March 14, 2014    Clinical Article
Exclusive Author Commentary

8 Hemoglobin A1c, fasting plasma glucose, and 2-hour plasma glucose distributions in U.S. population subgroups: NHANES 2005–2010 Annals of Epidemiology , February 13, 2014    Clinical Article

9 Clinical study of treatment switching from premixed insulin to basal insulin combined with oral hypoglycemic drugs in patients with type 2 diabetes Full Text Diabetology & Metabolic Syndrome, March 14, 2014    Free full text    Clinical Article

10 Comparing dosing of basal insulin analogues detemir and glargine: Is it really unit-per-unit and dose-per-dose? Annals of Pharmacotherapy, March 12, 2014    Clinical Article

11 Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (HARMONY 7): a randomised, open-label, multicentre, non-inferiority phase 3 study The Lancet Diabetes & Endocrinology, February 18, 2014    Clinical Article

12 Current thyroid cancer trends in the United States JAMA Otolaryngology—Head & Neck Surgery, March 3, 2014    Review Article

13 Comparison of extended release GLP-1 receptor agonist therapy versus sitagliptin in the management of type 2 diabetes Full Text Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, March 5, 2014    Free full text    Review Article

14 Effects of moderate-to-vigorous intensity physical activity on overnight and next-day hypoglycemia in active adolescents with type 1 diabetes Diabetes Care, March 3, 2014    Clinical Article

15 Cardiovascular risk profile in subjects with prediabetes and new-onset type 2 diabetes identified by HbA1c according to American Diabetes Association Criteria Diabetes Care, February 28, 2014    Clinical Article

16 The effect of L-thyroxine substitution on lipid profile, glucose homeostasis, inflammation and coagulation in patients with subclinical hypothyroidism International Journal of Clinical Practice, March 12, 2014    Clinical Article
Exclusive Author Commentary

17 Insulin pump use in pregnancy is associated with lower HbA1c without increasing the rate of severe hypoglycaemia or diabetic ketoacidosis in women with type 1 diabetes Diabetologia - Clinical and Experimental Diabetes and Metabolism, March 4, 2014    Clinical Article

18 Effects of sitagliptin on glycemia, incretin hormones, and antropyloroduodenal motility in response to intraduodenal glucose infusion in healthy lean and obese humans, and patients with type 2 diabetes treated with or without metformin Diabetes, March 26, 2014    Clinical Article

19 A higher-complex carbohydrate diet in gestational diabetes achieves glucose targets and lowers postprandial lipids: A randomized crossover study Diabetes Care, March 7, 2014

20 Alogliptin: Safety, efficacy, and clinical implications Journal of Pharmacy Practice, March 4, 2014    Review Article

Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetesmore

Other Topics in Endocrinology

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close