Safety and efficacy of everolimus-eluting stents versus paclitaxel-eluting stents in a Diabetic Population
Catheterization and Cardiovascular Interventions,  Clinical Article

Laynez A et al. – In a diabetic population undergoing percutaneous coronary intervention (PCI), the use of an everolimus–eluting stents (EES) compared to paclitaxel–eluting stents (PES) was associated with lower rates of stent thrombosis; but after adjustment the composite r target lesion revascularization (TLR)–major adverse cardiac events (MACE) at 1 year was similar between both stents.

Methods
  • From March 2004 to May 2010, 968 consecutive diabetic patients underwent percutaneous coronary intervention (PCI) and implantation of an EES (n=388) or PES (n=580) at this institution.
  • In–hospital, 1–month, 6–month, and 1–year clinical outcomes were analyzed and compared.
  • Correlates of major adverse cardiac events (MACE) were identified.

Results
  • Baseline clinical characteristics were similar between stent types except for more family history of coronary artery disease in the PES group and more insulin–dependent diabetes and unstable angina at initial diagnosis in the EES group.
  • The PES group had higher number of lesions treated, longer stents used, and a higher proportion of intravascular ultrasound and glycoprotein IIb/IIIa inhibitor use.
  • The EES group had more type C and distal lesions.
  • There was higher target lesion revascularization (TLR)–MACE in the PES group (3.3% vs. 1.0%, p=0.03) as well as a higher rate of stent thrombosis (ST) (8 patients vs. 0 in the EES group, p=0.03).
  • ST continued to be higher in the PES group at 6 and 12 months and mortality was higher at 12 months in the PES group (9.4% vs. 5.2%, p=0.02).
  • After adjustment, no significant differences were found between stent types on Cox regression analysis for hazard ratios at 1–year follow–up of TLR–MACE.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Endocrinology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Endocrinology Articles

1 Effects of 12 weeks high-dose vitamin D3 treatment on insulin sensitivity, beta cell function, and metabolic markers in patients with type 2 diabetes and vitamin D insufficiency – A double-blind, randomized, placebo-controlled trial Metabolism, July 9, 2014    Clinical Article

2 New insulin glargine 300 units/ml versus glargine 100 units/ml in people with type 2 diabetes using basal and mealtime insulin: Glucose control and hypoglycemia in a 6-month randomized controlled trial (EDITION 1) Diabetes Care, August 1, 2014    Clinical Article

3 Hypogonadal obese men with and without diabetes mellitus type 2 lose weight and show improvement in cardiovascular risk factors when treated with testosterone: An observational study Obesity Research & Clinical Practice, July 24, 2014    Clinical Article

4 Effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes: Randomized, double-blind, placebo-controlled trial Clinical Nutrition, August 6, 2014    Clinical Article

5 Comparison of the effects on glycaemic control and β-cell function in newly diagnosed type 2 diabetes patients of treatment with exenatide, insulin or pioglitazone: a multicentre randomized parallel-group trial (the CONFIDENCE study) Journal of Internal Medicine, August 1, 2014    Clinical Article

6 Lack of effect of aspirin in primary CV prevention in type 2 diabetic patients with nephropathy: results from 8 years follow-up of NID-2 study Acta Diabetologica, August 11, 2014    Clinical Article

7 Glycated hemoglobin as a marker of subclinical atherosclerosis and cardiac remodeling among non-diabetic adults from the general population Diabetes Research and Clinical Practice, June 27, 2014    Clinical Article

8 Insulin pump treatment compared with multiple daily injections for treatment of type 2 diabetes (OpT2mise): a randomised open-label controlled trial The Lancet, July 7, 2014    Evidence Based Medicine    Clinical Article

9 Effect of intensive diabetes treatment on albuminuria in type 1 diabetes: long-term follow-up of the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications study The Lancet Diabetes & Endocrinology, August 7, 2014    Clinical Article

10 Triple combination of insulin glargine, sitagliptin and metformin in type 2 diabetes: The EASIE Post-hoc Analysis and Extension Trial Journal of Diabetes and its Complications, August 28, 2014    Clinical Article

11 Adiponectin is better predictor of subclinical atherosclerosis than liver function tests in patients with nonalcoholic fatty liver disease Journal of the American Society of Hypertension, July 18, 2014    Clinical Article

12 Efficacy and safety of vitamin D3 in patients with diabetic nephropathy: a meta-analysis of randomized controlled trials Full Text Chinese Medical Journal, August 26, 2014    Free full text    Review Article

13 Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies Full Text Cardiovascular Diabetology, August 22, 2014    Free full text    Clinical Article

14 Combination therapy with sitagliptin and lansoprazole in patients with recent-onset type 1 diabetes (REPAIR-T1D): 12-month results of a multicenter, randomized, placebo-controlled, phase 2 trial The Lancet Diabetes & Endocrinology, July 21, 2014    Clinical Article

15 Comparative effects of metformin and pioglitazone on YKL-40 in type 2 diabetes: a randomized clinical trial Full Text Journal of Endocrinological Investigation, August 20, 2014    Free full text    Clinical Article

16 Statins and the risk of diabetes: Evidence from a large population-based cohort study Diabetes Care, July 3, 2014    Clinical Article

17 Drugs that interact with levothyroxine; an observational study from the Thyroid Epidemiology, Audit and Research Study (TEARS) Clinical Endocrinology, July 18, 2014    Clinical Article

18 Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial The Lancet, July 25, 2014    Evidence Based Medicine    Clinical Article

19 Once-weekly exenatide as adjunct treatment of type 1 diabetes mellitus in patients receiving continuous subcutaneous insulin infusion therapy Canadian Journal of Diabetes, August 5, 2014    Clinical Article

20 A randomized trial of step-up treatment with premixed insulin lispro-50/50 vs. aspart-70/30 in patients with type 2 diabetes mellitus Full Text Diabetes Therapy, August 27, 2014    Free full text    Clinical Article

Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetesmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close