The Effects of Long-Term Oral Benfotiamine Supplementation on Peripheral Nerve Function and Inflammatory Markers in Patients With Type 1 Diabetes: A 24-month, double-blind, randomized, placebo-controlled trial Full Text
Diabetes Care, 04/06/2012
Fraser DA et al. – The findings suggest that high–dose benfotiamine (300 mg/day) supplementation over 24 months has no significant effects upon peripheral nerve function or soluble markers of inflammation in patients with type 1 diabetes.Methods
- The study randomly assigned 67 patients with type 1 diabetes to receive 24–month benfotiamine (300 mg/day) or placebo supplementation.
- Peripheral nerve function and levels of soluble inflammatory variables were assessed at baseline and at 24 months.
- Fifty–nine patients completed the study.
- Marked increases in whole–blood concentrations of thiamine and thiamine diphosphate were found in the benfotiamine group (both P < 0.001 vs. placebo).
- However, no significant differences in changes in peripheral nerve function or soluble inflammatory biomarkers were observed between the groups.