Smoking and other factors associated with short-term partial remission of Type 1 diabetes in adults
Diabetic Medicine, 04/02/2012
Pilacinski S et al. - Relative to individuals in this study who smoked, those who did not smoke at diagnosis of Type 1 diabetes experienced a longer duration of partial remission.Methods
- The authors recruited 149 patients (48 women and 101 men, aged 16-35years, median age 25years), admitted to a teaching hospital with newly diagnosed Type 1 diabetes and followed them for a median period of 1year and 9months.
- The authors introduced intensive insulin therapy in multiple injections (basal-bolus) in all patients.
- The authors defined partial remission as an insulin dose of ≤0.3U/kg body weight/24h, an HbA1c value <53mmol/mol (7.0%) and a random serum C-peptide concentration over 0.5ng/ml.
- Cigarette smoking was determined by self-report.
- Of 149 patients, 68 (46%) fulfilled the criteria for partial remission at 1year after diagnosis of diabetes.
- Fewer patients who were in partial remission at 1year smoked (19/68, 28%) than did patients that were not in partial remission (41/81, 51%).
- In logistic regression analyses, non-smoking was associated with remission at 1year independent of age, sex, HbA1c and presence of diabetic ketoacidosis, all measured at onset of diabetes (OR 3.32, 95% CI 1.42-7.75, P=0.005).