Changes within the thyroid axis after long-term TSH-suppressive levothyroxine therapy
Clinical Endocrinology, 04/02/2012
Verburg FA et al. – After long–term TSH–suppressive LT4 therapy for differentiated thyroid carcinoma (DTC), there are significant changes in thyroid hormone metabolism, which are best explained by a combined downregulation of deiodinases subtypes 1 and 2 and an upregulation of deiodinase subtype 3.



