Cholesteryl Ester Transfer Protein and ATP-Binding Cassette Transporter A1 Genotype Alter the Atorvastatin and Simvastatin Efficacy: Time for Genotype-Guided Therapy

Angiology, 05/16/2012

Kolovou G – The TaqIB and R219K (opposite to I405V) gene polymorphisms seem to modify the response to lipid–lowering therapy with simvastatin or atorvastatin treatment.

Methods

  • The authors compared the efficacy of atorvastatin with simvastatin according to cholesteryl ester transfer protein (CETP) and adenosine triphosphate–binding cassette transporter A1 (ABCA1) genes.
  • Patients treated with atorvastatin (n = 254) or simvastatin (n = 332) were genotyped for CETP (TaqIB and I405V) and ABCA1 (R219K) genetic variants.

Results

  • For genotype B1B2, atorvastatin compared with simvastatin treatment resulted in a greater decrease in total cholesterol (35.4% vs 31.6%, P = .035) and a lower increase in high–density lipoprotein cholesterol (2% vs 8%, P = .05).
  • For genotype B2B2, atorvastatin compared with simvastatin treatment resulted in a lower decrease in low–density lipoprotein cholesterol (31.85 vs 42%, P = .029).
  • For genotypes RR and KK, atorvastatin compared with simvastatin treatment resulted in a greater decrease of triglycerides (27% vs 17% and 35% vs 15%, respectively; P = .02 for all comparisons).

Print Article Summary Cat 2 CME Report