Hyperthyrotropinaemia in untreated subjects with downs syndrome aged 6 months to 64 years: a comparative analysis

Archives of Diseases in Childhood, 05/14/2012

Down's syndrome is associated with higher thyroid–stimulating hormone (TSH) levels. The results suggest that hyperthyrotropinaemia is an innate attribute of chromosome 21 trisomy. Therefore, T4 treatment should not be contemplated in Down's Syndrome unless the TSH is >95th centile in the presence of normal–range free T4 levels.

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