Improved diagnostic accuracy for neuroendocrine neoplasms using two chromogranin A assays

Clinical Endocrinology, 05/11/2012

Ramachandran R et al. – Although individually, all four Chromogranin A (Cg A) assays are similarly useful for the measurement of Cg A in the diagnosis of a NEN, in patients with a suspected neuroendocrine neoplasms (NENs), negative results by one assay should prompt analysis by a second assay. The combination of Cisbio and SAS assays may have greatest diagnostic utility.


  • Plasma Cg A was measured using these four assays in 125 patients with NENs, 41 patients with cancers other than NENs and 108 healthy controls.


  • There was no significant difference in diagnostic accuracy between any of the four assays alone and no single assay positively identified all patients with NEN.
  • However, concordance between assays was variable. Cisbio and SAS assays were least concordant.
  • Consistent with hypothesis, multiple logistic regression analysis showed that the combination of Cisbio and SAS assays was more useful than any other combinations or any assay alone in predicting a NEN diagnosis.

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