Improved diagnostic accuracy for neuroendocrine neoplasms using two chromogranin A assays
Clinical Endocrinology, 05/11/2012
Ramachandran R et al. – Although individually, all four Chromogranin A (Cg A) assays are similarly useful for the measurement of Cg A in the diagnosis of a NEN, in patients with a suspected neuroendocrine neoplasms (NENs), negative results by one assay should prompt analysis by a second assay. The combination of Cisbio and SAS assays may have greatest diagnostic utility.
Plasma Cg A was measured using these four assays in 125 patients with NENs, 41 patients with cancers other than NENs and 108 healthy controls.
There was no significant difference in diagnostic accuracy between any of the four assays alone and no single assay positively identified all patients with NEN.
However, concordance between assays was variable. Cisbio and SAS assays were least concordant.
Consistent with hypothesis, multiple logistic regression analysis showed that the combination of Cisbio and SAS assays was more useful than any other combinations or any assay alone in predicting a NEN diagnosis.
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