Glucose fluctuations in subjects with normal glucose tolerance, impaired glucose regulation and newly diagnosed type 2 diabetes mellitus

Clinical Endocrinology, 05/11/2012

Wang C et al. – Glucose variability is present to an increasing degree from normal glucose tolerance (NGT) to impaired glucose regulation (IGR) and IGR to DM–2. Compared with the NGT individuals, the IGR and DM–2 subjects show more predominant intraday glucose fluctuations. The DM–2 patients demonstrate increased PPGEs, higher glucose levels overnight and greater interday fluctuations.


  • Mean blood glucose (MBG), standard deviation of MBG (SDBG), largest amplitude of glycemic excursions (LAGE) and mean amplitude of glycemic excursions (MAGE) were calculated to estimate intraday blood glucose variability.
  • Interday variability of glucose was evaluated by absolute means of daily differences (MODD).
  • Postprandial glucose excursion (PPGE) was calculated to assess the influence of meals on glucose fluctuation.


  • Twenty-two percentage of NGT and 33•9% of IGR individuals experienced blood glucose >11•1mmol/l; 49•1% of NGT, 50•9% of IGR and 30•8% of DM-2 participants had hypoglycemic episodes.
  • The IGR and DM-2 groups had greater SDBG, LAGE and MAGE compared with the NGT group.
  • Significantly greater MODD and PPGEs were found in the DM-2 groups than in the IGR and NGT groups.
  • In the patients with diabetes, MAGE was positively associated with MODD and PPGEs.

Print Article Summary Cat 2 CME Report