Discontinuation of statins among patients with type 2 diabetes
Diabetes/Metabolism Research and Reviews, 05/04/2012Lamberts EJF et al.
Patients starting statins after the initiation of oral anti–diabetic treatment are more likely to discontinue treatment than patients who initiate statins before the start of oral anti–diabetics.
The authors report an observational cohort study among patients initiating treatment with statins prior to or after initiation of oral anti–diabetics between 1999 and 2007.
Patients were classified as starting statins prior to initiation (Prior users) or after initiation (After users) of anti–diabetics.
Discontinuation was defined as an interval of 180 days or more between the theoretical end date of a statin/anti–diabetic prescription and the dispensing date of the next statin/anti–diabetic prescription.
The authors included 3323 starters with oral anti–diabetic drugs in their study; 2072 patients initiated statins in the period of observation.
Discontinuation rates for statins were higher compared with oral anti–diabetics (52.1 vs 15.0%).
After users discontinued statin therapy more frequently compared to prior users (62.8 vs 48.2%).
Discontinuation of statins is higher compared with anti–diabetic discontinuation.
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