High glucose concentrations induce TNF-alpha production through the down-regulation of CD33 in primary human monocytes

BMC Immunology, 05/03/2012

The results suggest that hyperglycemia down–regulates CD33 expression and triggers the spontaneous secretion of TNF–alpha by peripheral monocytes. This phenomenon involves the generation of ROS and the up–regulation of SOCS–3. These observations support the importance of blood glucose control for maintaining innate immune function and suggest the participation of CD33 in the inflammatory profile associated with type 2 diabetes.

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