Isomaltulose Improves Glycemia and Maintains Run Performance in Type 1 Diabetes

Medicine and Science in Sports and Exercise, 04/20/2012

Bracken RM et al. – Consumption of isomaltulose alongside rapid–acting insulin reduction improves Blood glucose (BG) responses to exercise and produces a similar high–intensity run performance compared with dextrose in type 1 diabetes mellitus (T1DM) individuals.


  • After preliminary testing, on two occasions, seven T1DM individuals consumed 0.6 g•kg–1 body mass of either dextrose (DEX; glycemic index = 96) or isomaltulose (ISO; glycemic index = 32), 2 h before a discontinuous incremental run to 80% V’O2peak on a motorized treadmill followed by a 10–min all–out performance test on a nonmotorized treadmill.
  • Blood glucose (BG), acid–base, and cardiorespiratory parameters were measured 2 h before, during, and after both run tests.
  • Data (mean ± SEM) were analyzed using repeated–measures ANOVA.


  • Preexercise BG area under the curve was lower under ISO in comparison with DEX (ISO = +4.0 ± 0.3 mmol•L–1•h–1 vs DEX = +7.0 ± 0.6 mmol•L–1•h–1, P < 0.01).
  • Resting blood lactate concentrations and rate of CHO oxidation under ISO were greater than those elicited under DEX (P < 0.05).
  • There were no metabolic or cardiorespiratory differences between conditions in response to submaximal exercise despite lower BG concentrations under ISO (P < 0.05).
  • T1DM individuals completed the same distance at the same speed during the 10–min run test under both conditions (not significant).

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