Pinguecula and Diabetes Mellitus

Cornea, 03/14/2012

Mimura T et al. – This is the first assessment of the relationship between pinguecula and diabetes mellitus. The results suggest that diabetes mellitus may be a factor associated with the development of pinguecula.


  • A total of 160 patients with type 2 diabetes aged 31 to 70 years (DM group) and 160 control subjects aged 31 to 70 years (control group) were enrolled.
  • The grade of pinguecula at 2 locations (nasal and temporal) was assessed in all subjects by a grading system.


  • There was an age-related increase in the grade of pinguecula in both the DM group (r = 0.52; P < 0.0001) and the control group (r = 0.51; P < 0.0001).
  • The grade and prevalence of pinguecula were higher in the DM group than in the control group for pinguecula of the nasal conjunctiva (grade: P < 0.0001; and prevalence: 55.0% vs. 40.0%, P = 0.0072) and the temporal conjunctiva (grade: P < 0.0001; and prevalence: 54.4% vs. 40.0%, P = 0.0100).
  • Multivariate logistic regression analysis revealed that age and diabetes were associated with an increased prevalence of nasal or temporal pinguecula (all P < 0.05).
  • Diabetes mellitus was independently associated with the severity of pinguecula (nasal: odds ratio = 1.19; temporal: odds ratio = 1.22) after adjustment for age.

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