Mapping the growth hormone-Stat5b-IGF-I transcriptional circuit

Trends in Endocrinology and Metabolism, 02/24/2012

Rotwein P – This review summarizes the potentially complex mechanistic relationship between Growth hormone (GH) action, Stat5b, and insulin–like growth factor–I (IGF–I) gene activation, and suggests that Stat5b may have a broad role in mediating IGF–I gene regulation in response to diverse physiological inputs.

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