Endocrinology News & Articles

1 Adult growth hormone deficiency – benefits, side effects, and risks of growth hormone replacement Frontiers in Endocrinology, June 19, 2013
Reed ML et al. - Deficiency of growth hormone (GH) in adults results in a syndrome characterized by decreased muscle mass and exercise capacity, increased visceral fat, impaired quality of life, unfavorable alterations in lipid profile and markers of cardiovascular risk, decrease in bone mass and integrity, and increased mortality. The potential of GH to act as a mitogen has resulted in concern over the possibility of increased de novo tumors or recurrence of pre-existing ...

2 Epiphyseal growth plate growth hormone receptor signaling is decreased in chronic kidney disease-related growth retardation Kidney International, May 30, 2013
Troib A et al. - Linear growth retardation in children with chronic kidney disease (CKD) has been ascribed to insensitivity to growth hormone. This resistance state has been attributed to impaired growth hormone signaling through the JAK2/STAT5 pathway in liver and skeletal muscle leading to reduced insulin-like growth factor-I (IGF-I). Linear growth impairment in CKD can in part be explained by impaired long bone growth plate growth hormone receptor signaling through ...

3 Adult growth hormone deficiency – benefits, side effects, and risks of growth hormone replacement Frontiers in Endocrinology, April 24, 2013
Reed ML et al. - Deficiency of growth hormone (GH) in adults results in a syndrome characterized by decreased muscle mass and exercise capacity, increased visceral fat, impaired quality of life, unfavorable alterations in lipid profile and markers of cardiovascular risk, decrease in bone mass and integrity and increased mortality. The potential of GH to act as a mitogen has resulted in concern over the possibility of increased de novo tumors or recurrence of pre-existing ...

4 Novel compound heterozygous mutations of the growth hormone-releasing hormone receptor gene in a case of isolated growth hormone deficiency Growth Hormone & IGF Research, June 6, 2013
Soneda A et al. - The study aims to elucidate the pathogenesis of isolated growth hormone (GH) deficiency in a Japanese girl without consanguinity. A case of isolated GH deficiency due to novel GHRHR gene mutations was identified.

5 Growth Hormone Therapy Helping Kids With Kidney Failure Ivanhoe, April 8, 2013
Chronic kidney disease can have severe effects on growth in children, leading to short stature and problems with both physical and psychological health. Abnormally high or abnormally low bone turnover can increase the severity of growth retardation in children with kidney disease, so finding a normal balance is important. Recombinant human growth hormone can often help, but response is variable in children on dialysis. To evaluate the direct effect of recombinant human growth hormone therapy ...

6 Influence of glucocorticoids and growth hormone on insulin sensitivity in humans Diabetic Medicine, March 21, 2013
Yuen KCJ et al. - The seminal concept, proposed by Sir Harold Himsworth more than 75 years ago, that a large number of patients with diabetes were ‘insulin insensitive’, now termed insulin resistance, has now expanded to include several endocrine syndromes, namely those of glucocorticoid excess, and growth hormone excess and deficiency. In this review, the authors describe the physiological events that result from the presence of resistance to insulin action at the level of skeletal ...

7 The role of human growth hormone's C-terminal disulfide bridge Growth Hormone & IGF Research, April 19, 2013
Junnila RK et al. - Human growth hormone (hGH), as well as the other members of the same polypeptide hormone family, have a four-helix bundle structure linked by two disulfide bridges, C53–C165 and C182–C189 in hGH. The C-terminal disulfide bridge of growth hormone is evolutionally conserved but its role is unknown. The aim was to determine its importance for GH structure and/or function. The study reveals the importance of the C-terminal disulfide bridge of GH for ...

8 Different Long-Term Response to Growth Hormone Therapy in Small- versus Appropriate-for-Gestational-Age Children with Growth Hormone Deficiency Hormone Research in Paediatrics, April 26, 2013
Meazza C et al. - The role of birth weight on growth hormone (GH) therapy response in GH-deficient (GHD) children has not been fully elucidated. Therefore, the authors examined the growth of 23 small-for-gestational-age GHD children (SGA-GHD, 11 females and 12 males), 26 appropriate-for-gestational-age GHD children (AGA-GHD, 11 females and 15 males) during the first 5 years of GH therapy and that of 22 non-GH-treated SGA ...

9 Efficacy and Safety of LB03002, a Once-Weekly Sustained-Release Human Growth Hormone for 12-Month Treatment in Korean Children with Growth Hormone Deficiency European Journal of Endocrinology, May 20, 2013
Hwang JS et al. - The purpose of this study was to investigate the efficacy and safety of LB03002, a sustained-release growth hormone (SR-hGH), compared to that of daily rhGH for 12 months in children with growth hormone deficiency. Weekly injection of LB03002 at a dose of 0.5 mg/kg/wk was confirmed to have comparable efficacy to daily injection of daily rhGH at a dose of 0.21 mg/kg/wk. Both formulations were well tolerated.

10 Efficacy and safety of LB03002, a once-weekly sustained-release human growth hormone for 12-month treatment in korean children with growth hormone deficiency European Journal of Endocrinology, June 10, 2013
Hwang JS et al. - The purpose of this study was to investigate the efficacy and safety of LB03002, a sustained-release growth hormone (SR-hGH), compared to that of daily rhGH for 12 months in children with growth hormone deficiency. Weekly injection of LB03002 at a dose of 0.5 mg/kg/wk was confirmed to have comparable efficacy to daily injection of daily rhGH at a dose of 0.21 mg/kg/wk. Both formulations were well tolerated.